Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq and ChIP-seq profiling of human iPSCs, derived NSCs and human fetal NSCs

ABSTRACT: RNA-seq and ChIP-seq profiling of human iPSCs, derived NSCs and human fetal NSCs

PROVIDER: PRJNA999314 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25442735_1.fastq.gz	Fastqsanger.gz
	SRR25442735_2.fastq.gz	Fastqsanger.gz
	SRR25442736_1.fastq.gz	Fastqsanger.gz
	SRR25442736_2.fastq.gz	Fastqsanger.gz
	SRR25442737_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 84

Similar Datasets

RNA-seq and ChIP-seq profiling of human iPSCs, derived NSCs and human fetal NSCs (ChIP-Seq)

Project description:RNA-seq and ChIP-seq profiling of human iPSCs, derived NSCs and human fetal NSCs (ChIP-Seq)

| PRJNA999317 | ENA

RNA-seq and ChIP-seq profiling of human iPSCs, derived NSCs and human fetal NSCs (RNA-Seq)

Project description:RNA-seq and ChIP-seq profiling of human iPSCs, derived NSCs and human fetal NSCs (RNA-Seq)

| PRJNA999318 | ENA

Human ESCs vs Human iPSCs & Human NSCs-ES vs Human NSCs-iPS

Project description:Transcriptional profiling of Human ESCs vs Human iPSCs, Human NSCs-ES vs Human NSCs-iPS iPSCs generated by using different method, and are not very good at Neural differentiation comapred with Human ESCs

2016-09-29 | GSE67325 | GEO

RNA-seq and ChIP-seq profiling of human iPSCs, derived NSCs and human fetal NSCs (RNA-Seq)

Project description:Human iPSC-derived neural stem/progenitor cells (hiPSC-NSCs) are a promising source for cell/gene therapy approaches to target neurodegenerative and demyelinating disorders with unmet clinical needs. Despite the great effort in characterizing hiPSC-derived products in both in vitro and in vivo settings, we still lack a comprehensive study addressing hiPSC-NSC identity and safety at genome-wide level, an issue of paramount importance to establish accepted criteria for prospective clinical applications. Here, we evaluated the transcriptional (by poly-A+ RNA-seq) and epigenetic (by H3K27Ac ChIP-seq) signatures in hiPSCs and differentiated hiPSC-NSC progeny, keeping as reference a somatic clinically relevant human fetal NSC (hfNSCs) line. Overall, our comprehensive transcriptomic and epigenomic analysis coupled to a long-term functional in vivo characterization provided insight into the cell identity, safety profile, and therapeutic potential of hiPSC-NSCs, supporting the rationale for the continuous development of hiPSC-NSCs as an alternative source to somatic hfNSCs for treatment of neurodegenerative and demyelinating disorders.

2024-09-23 | GSE239444 | GEO

RNA-seq and ChIP-seq profiling of human iPSCs, derived NSCs and human fetal NSCs (ChIP-Seq)

2024-09-23 | GSE239443 | GEO

Genome-wide analysis of gene expression in human iPSCs and NSCs engineered by safe-harbor TALEN-mediated gene targeting

Project description:Human iPSCs and NSCs were engineered by AAVS1 and/or C13 safe-harbor TALENs which mediated targeted integration of various reporter genes at single or dual safe-harbor loci. Multiple clones of targeted human iPSCs were used to compare with parental untargeted NCRM5 iPSCs. Polyclonal targeted human NSCs were used to compare with their parental untargeted NCRM1NSCs or H9NSCs. Total RNA obtained from targeted human iPSCs or NSCs compared to untargeted control iPSCs or NSCs.

2014-09-01 | E-GEOD-55975 | biostudies-arrayexpress

RNA-seq in SREBF1-deficient human iPSCs, hiPSC-NSCs and differentiated cells.

Project description:RNA-seq in SREBF1-deficient human iPSCs, hiPSC-NSCs and differentiated cells.

| PRJNA1140208 | ENA

Genome-wide analysis of gene expression in human iPSCs and NSCs engineered by safe-harbor TALEN-mediated gene targeting

2014-09-01 | GSE55975 | GEO

Human expression data from iPSCs, motor neurons derived from iPSCs and ESCs, and fetal spinal cords

Project description:We compare transcriptomic profiles of human induced pluripotent stem cells (iPSCs), motor neurons (MNs) in vitro differentiated from iPSCs or human ESCs containing a HB9::GFP reporter for MNs, and human fetal spinal cords. The purpose of this comparison is to assess the extent of molecular similarities between in vitro differentiated MNs and in vivo fetal or adult spinal cord MNs. Data for adult spinal cord MNs are published from other studies: GSE3526, GSE19332, GSE20589, and GSE40438.

2016-06-26 | GSE75701 | GEO

Human expression data from iPSCs, motor neurons derived from iPSCs and ESCs, and fetal spinal cords

2016-06-26 | E-GEOD-75701 | biostudies-arrayexpress