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Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [RNA-seq trx]

ABSTRACT: Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [RNA-seq trx]

PROVIDER: PRJNA999448 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25443678.fastq.gz	Fastqsanger.gz
	SRR25443679.fastq.gz	Fastqsanger.gz
	SRR25443680.fastq.gz	Fastqsanger.gz
	SRR25443681.fastq.gz	Fastqsanger.gz
	SRR25443682.fastq.gz	Fastqsanger.gz

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Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons.

Project description:Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons.

| PRJNA999446 | ENA

Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [ChIP-seq]

Project description:Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [ChIP-seq]

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Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [RNA-seq trx]

Project description:We have analyzed changes in histone H3 lysine 4 methylation (H3K4me) and gene expression resulting from trx knockdown (KD) in adult mushroom body neurons of Drosophila melanogaster.

2024-12-17 | GSE239491 | GEO

Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [RNA-seq Set1 & trr]

Project description:Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [RNA-seq Set1 & trr]

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Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [ChIP-seq]

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Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [RNA-seq Set1 & trr]

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An epigenetic mark of polycomb response elements implemented by Trx/MLL/COMPASS

Project description:In Drosophila, Polycomb Response Elements (PREs) are identified as genomic sequences allowing the maintenance of transcriptional repression in the absence of the initiating signal. Although PREs in Drosophila are well characterized, the existence of mammalian PRE-like elements remains debated. Accumulating evidence supports a model in which CpG islands function to recruit Polycomb-Group complexes (PcG), however, it is not evident which subclasses of CpG islands serve as PREs. Trithorax (Trx), which is required for positive regulation of gene expression in Drosophila, is known to co-bind Drosophila PREs where it is thought to antagonize polycomb-dependent silencing of nearby genes. Here, we demonstrate the existence of Trx-dependent H3K4 dimethylation loci that specifically mark Drosophila PREs and are required for the maintenance of expression of the nearby genes. Similarly, in human cells, we find ~ 3000 MLL1 (human Trx homologue)-dependent H3K4 dimethylation loci, which correlate strongly with CpG island density. In the absence of MLL1 and H3K4 dimethylation at these loci, there is an increase in H3K27 trimethylation levels, suggesting these sites can recruit Polycomb Repressive Complex 2 (PRC2). By inhibiting PRC2-dependent silencing in the absence of MLL1, we establish that a balance exists between MLL1 and PRC2, and their respective capacity to maintain or repress transcription. Thus, by investigating a conserved function between Trx and MLL1, we provide rules for the identification of CpG island subclasses serving as PRE-like sequences within the human genome. To examine changes in histone-modification profiles and gene expression after depletion of Trx in Drosophila S2 cells, and MLL1 in human HCT116 cells. We also treated MLL1-NULL HCT116 cells with GSK126 (5uM) for 4 days and measured changes in gene expression.

2016-07-26 | E-GEOD-81795 | biostudies-arrayexpress

trx regulatory gene network in D. melanogaster

Project description:This SuperSeries is composed of the following subset Series: GSE8748: Chromosomal clustering of genes in trithorax (trx) mutant larvae GSE8750: Chromosomal clustering of genes in absent, small, or homeotic discs 2 (ash2) mutant larvae Keywords: SuperSeries Refer to individual Series

2010-06-25 | E-GEOD-8783 | biostudies-arrayexpress

Chromosomal clustering of genes in trithorax (trx) mutant larvae

Project description:We have performed a systematic examination of genome-wide expression profiles using microarrays to reconstruct a global picture of the trx regulatory gene network in D. melanogaster. Using computational analysis of the microarray data, we have identified 25 clusters of genes potentially regulated by trx, most of them being located in the arm L of chromosome 3. Functional analysis revealed that most clusters are enriched in structural proteins involved in cuticle formation, which are preferently expressed in salivary glands. The same organization in clusters was observed in the transcriptomes of four independent experiments, being a distinctive feature of the regulatory networks of trx and other chromatin regulators (ASH2, NURF, Pc, ASH1). We have also identified many of these clusters in D. simulans, D. yakuba, D. pseudoobscura and partially in A. gambiae. Keywords: loss of function analysis

2008-09-26 | GSE8748 | GEO

An epigenetic mark of polycomb response elements implemented by Trx/MLL/COMPASS

2016-07-26 | GSE81795 | GEO