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ProteomicsTransformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1
Telomeres play crucial roles during tumorigenesis inducing cellular senescence upon telomere shortening and extensive chromosome instability during telomere crisis. However, it has not been investigated if and how cellular transformation and oncogenic stress alters telomeric chromatin composition and...
ORGANISM(S): Homo Sapiens (human) 
2018-07-13 | PXD010088 | Pride
Telomeres Transformation Quantitative proteomics Replication stress Samhd1 
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ProteomicsTelomeric protein composition deriving from q-TIP analysis comparing Hela supertelomerase cells, Hela TRF2 knockdown cells or Hela POT1 knockdown cells with Hela control cells, proteomes by 2D-LC-MS/MS
All samples derived from the q-TIP experiments were analysed using reverse-phase chromatography coupled to orbitrap high-resolution mass spectrometer using trypsin digestion. MS/MS files were searched against the UniProt human protein database (release date 18-04-2012) by MaxQuant software (version 1...
ORGANISM(S): Homo Sapiens (human) 
2013-11-26 | PXD000243 | Pride
Human Chromatin Telomer length Lc-ms/ms Silac Telomers 
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ProteomicsPeroxiredoxin 1 protects telomeres from oxidative damage preserving chromosome ends for extension by telomerase
With the increase of atmospheric oxygen 2.3 billion years ago, mechanisms evolved to mitigate the toxic effects of oxygen radicals. Telomeres appear particularly susceptible to oxidative damage, which leads to cellular and organismal aging, cancer, cardiac failure and other diseases. Specific mechani...
ORGANISM(S): Homo Sapiens (human) 
2016-12-07 | PXD002626 | Pride
telomerase Peroxiredoxin 1  telomeres  oxidative damage  telomerase Peroxiredoxin 1 telomeres oxidative damage 
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UnknownWhite matter abnormalities are related to microstructural changes in preterm neonates at term-equivalent age: a diffusion tensor imaging and probabilistic tractography study.
Not available
S-EPMC7968822 | biostudies-literature
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UnknownThe canonical pathway for selenocysteine insertion is dispensable in Trypanosomes.
Not available
S-EPMC2664009 | biostudies-literature
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UnknownVibrio coralliilyticus strain OCN008 is an etiological agent of acute Montipora white syndrome.
Not available
S-EPMC3993142 | biostudies-literature
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UnknownEcological and molecular characterization of a coral black band disease outbreak in the Red Sea during a bleaching event.
Not available
S-EPMC6046197 | biostudies-literature
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UnknownA comparative baseline of coral disease in three regions along the Saudi Arabian coast of the central Red Sea.
Not available
S-EPMC8270217 | biostudies-literature
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UnknownDevelopment of a new chlamydiales-specific real-time PCR and its application to respiratory clinical samples.
Not available
S-EPMC3147821 | biostudies-literature
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UnknownHow to improve automated external defibrillator placement for out-of-hospital cardiac arrests: A case study.
Not available
S-EPMC8136701 | biostudies-literature
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