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ProteomicsMaxQuant.Live enables enhanced selectivity and identification of peptides modified by endogenous SUMO and ubiquitin
Small ubiquitin-like modifiers (SUMOs) and ubiquitin are frequent post-translational modifications of proteins that play pivotal roles in all cellular processes. We previously reported mass spectrometry-based proteomics methods that enable profiling of lysines modified by endogenous SUMO or ubiquitin...
ORGANISM(S): Homo Sapiens (human) 
2021-02-05 | PXD022367 | Pride
Ubiquitin Maxquant.live Sumo Mql Precursor untargeting Peptide mass filtering 
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ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinome...
ORGANISM(S): Homo Sapiens (human) 
2022-05-23 | PXD030644 | Pride
Lc-ms/ms The ubiquitin-proteasome system Dia 
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ProteomicsDDI2 is a ubiquitin-directed endoprotease, responsible for cleavage of transcription factor NRF1
The Ddi1/DDI2 proteins are ubiquitin shuttling factors, implicated in a variety of cellular functions. In addition to ubiquitin-binding and ubiquitin-like domains, they contain a conserved region with similarity to retroviral proteases, but whether and how DDI2 functions as a protease has remained un...
ORGANISM(S): Homo Sapiens (human) 
2020-06-24 | PXD019152 | Pride
Ubiquitin Hph Lc-ms/ms Ubisite Ddi2 Prm 
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ProteomicsAdipose MDM2 regulates systemic insulin sensitivity through nuclear import of MORC2 and the PPARγ cofactor LIPIN1
The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in their...
ORGANISM(S): Mus Musculus (mouse) 
2022-02-15 | PXD020812 | Pride
C/ebp Obesity Lipin1 Mdm2 Pparγ Morc2 
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ProteomicsThe placenta has an active role in maintaining fetal homeostasis following maternal immune activation
Activation of the maternal immune system during pregnancy can fetal development, which can lead to postnatal susceptibility to a wide range of diseases, including cardiovascular, metabolic and psychiatric disorders. During maternal immune activation (MIA), the maternal body must balance its ressource...
ORGANISM(S): Mus Musculus (mouse) 
2024-06-13 | PXD039402 | Pride
Fetal liver Phosphoproteomics Mouse placenta Lc-ms/ms 
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ProteomicsEGF-dependent ubiquitinome, phosphorylation and interactome analysis in control and CYLD-deficient cells
Cylindromatosis tumor suppressor protein (CYLD) is deubiquitinase, best known as an essential negative regulator of the NFkB pathway. Previous studies have suggested an involvement of CYLD in epidermal growth factor (EGF)-dependent signal transduction as well, as it was found enriched within the tyro...
ORGANISM(S): Homo Sapiens (human) 
2017-06-05 | PXD006390 | Pride
Hela Ubiquitin Phosphorylation Prm Egfr Cyld 
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ProteomicsMagnitude of ubiquitination determines the fate of activated epidermal growth factor receptor and downstream cellular effects
...and are critical for cell proliferation and differentiation. Their dysregulation leads to a loss of growth control, often resulting in cancer. Epidermal growth factor receptor (EGFR) is the prototypic RTK and can bind several ligands exhibiting distinct mitogenic potentials. Whereas the phosphorylat...
ORGANISM(S): Homo Sapiens (human) 
2022-05-31 | PXD019621 | Pride
Ubiquitin Signaling Tgf Aqua Egf Proteomics Rtk Mathematical modelling Epiregulin Mass spectrometry Egfr 
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ProteomicsPhosphoproteomic and functional approaches reveal changes in sperm-specific proteins downstream KOR in human spermatozoa
G-protein coupled receptors (GPCRs) belong to the seven transmembrane receptors superfamily that in response to external stimuli, transduce signals via G proteins to initiate different intracellular signaling pathways which culminate in specific cellular responses. Although in somatic cells the GPCR ...
ORGANISM(S): Homo Sapiens (human) 
2019-01-11 | PXD011290 | Pride
Phosphoproteomics Kor Human spermatozoa 
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ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinome...
ORGANISM(S): Homo Sapiens (human) 
2022-05-23 | PXD027330 | Pride
Human His10-ub Ubiquitin U2os Pr619 Mg132 Tak243 
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ProteomicsNuclear phosphoproteomics analysis of resting and IL-2-stimulated T lymphocytes
The aim of the present project was to study in detail the site-specific phosphorylation events occurring both in resting as well as in T lymphocytes stimulated with IL-2 for five minutes. For that purpose we combined SILAC-based quantitative mass spectrometry analysis with phosphopeptide enrichment u...
ORGANISM(S): Homo Sapiens (human) 
2016-04-18 | PXD002839 | Pride
Nucleus Phosphorylation T-lymphocyte Il-2 
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