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TranscriptomicsEgr2-dependent expression in T cell anergy
T cell anergy is one of the mechanisms contributing to peripheral tolerance, particularly in the context of progressively growing tumors and in tolerogenic treatments promoting allograft acceptance. We recently reported that early growth response gene 2 (Egr2) is a critical transcription factor for ...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46242 | biostudies-arrayexpress
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GenomicsGenome-wide maps of EGR2 transcription factor binding sites in T cell anergy
We report the application of sequencing technology for mapping the EGR2 transcriptional program in T cell anergy Examination of Egr2 genomic binding sites in T cells following overnight treatment with immobilized anti-CD3 mAb (1ug/ml)
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46241 | biostudies-arrayexpress
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TranscriptomicsNKT, CD1d-aGC+ Va24-, and CD4 T cell clones from human peripheral blood
Microarray analysis was performed to determine the transcriptional profiles of NKT, CD1d-aGC+ Va24-, and CD4 T cells. Clones of NKT, CD1d-aGC+ Va24-, and CD4 T cells were generated using peripheral blood drawn from two healthy individuals. RNA was extracted from cells that had been either rested (18...
ORGANISM(S): Homo sapiens 
2011-04-22 | E-GEOD-28726 | biostudies-arrayexpress
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UnknownLysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer.
Not available
S-EPMC2693181 | biostudies-literature
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TranscriptomicsPLZF expression maps the early stages of ILC1 lineage development
Diverse populations of natural killer cells, which exert critical early cytolytic functions against virally infected cells, have recently been uncovered, raising issues of lineage relationships. We used expression of the transcription factor PLZF to identify the developmental intermediates of ILC1s, ...
ORGANISM(S): Mus musculus 
2015-02-13 | E-GEOD-65898 | biostudies-arrayexpress
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TranscriptomicsGene expression changes in CD4+ thymocytes upon removal of Cullin3
We report gene expression changes in Cul3 deficient thymic CD4+ T cells We used microarrays to detail the global programme of gene expression changes upon removal of Cul3 during thymic development CD25-, CD1dPBS57-, gdTCR - CD4+ Single positive cells from thymocytes of CD4Cre-Cul3fl/fl (LM) and CD4 C...
ORGANISM(S): Mus musculus 
2014-04-05 | E-GEOD-56514 | biostudies-arrayexpress
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