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ProteomicsReceptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase 2A signaling in cardiac myocytes by nitroxyl
Sympathetic activation is the main driver of cardiac inotropy and lusitropy. Stimulation of the -adrenoceptor (AR) signaling cascade leads to activation of cAMP-dependent protein kinase (PKA) and subsequent cardiac protein phosphorylation, which is counteracted by the corresponding protein phosphatas...
ORGANISM(S): Rattus Norvegicus (rat) 
2020-10-29 | PXD019808 | Pride
Phosphorylation Nitroxyl Rat Kinase Oxidation Cardiac myocyte Phosphatase 
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Genomics,MultiomicsFramingham Cohort

Startup of Framingham Heart Study. Cardiovascular disease (CVD) is the leading cause of death and serious illness in the United States. In 1948, the Framingham Heart Study (FHS) -- under the direction of the National Heart Institute (now known as the National Heart, Lung, and Blood Institut...

phs000007.v17.p6 | EGA
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