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ProteomicsComparative proteomic analysis provides novel insights into the regulation mechanism underlying the fruit ripening process in papaya (Carica papaya L.)
Papaya (Carica papaya L.) is a typical climacteric fruit, undergoing massive physico-chemical changes during ripening. Although papaya is widely cultivated and consumed, few studies have characterized the variations in metabolism during its ripening process at the proteasome level. Using an integrated approach involving Tandem Mass Tag labeling and liquid chromatography–mass spectrometry analysis, proteomes of papaya fruit at di...
... and diverse subcellular localizations. Among the DEPs, most of the pathogen defense-related proteins were down-regulated, suggesting that disease resistance decreased during the ripening process. The Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that various metabolic pathways were significantly altered, particularly in flavonoid and fatty acid metabolisms. The up-regulation of several flavonoid biosynthesis-related proteins may provide more raw materials for pigment biosynthesis, acceler...
ORGANISM(S): Carica Papaya 
2019-11-12 | PXD008871 | Pride
Ripening Papaya Differential expressed protein Fatty acid Metabolism 
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UnknownIdentification of naturally occurring inhibitors in Xian-Ling-Gu-Bao capsule against the glucuronidation of estrogens.
Not available
S-EPMC9386001 | biostudies-literature
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UnknownHerbal Fufang Xian Ling Gu Bao prevents corticosteroid-induced osteonecrosis of the femoral head-A first multicentre, randomised, double-blind, placebo-controlled clinical trial.
Not available
S-EPMC5866478 | biostudies-literature
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UnknownSimultaneous Quantification of Multiple Representative Components in the Xian-Ling-Gu-Bao Capsule by Ultra-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry.
Not available
S-EPMC6152775 | biostudies-literature
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UnknownIdentification, bioactivity evaluation and pharmacokinetics of multiple components in rat serum after oral administration of Xian-Ling-Gu-Bao capsule by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.
Not available
S-EPMC6338342 | biostudies-literature
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ProteomicsRat Serum Exosome LC-MSMS(Label free)
LC-MSMS (Label free) was performed to find differential proteins in maternal rat serum exosome between 3 normal pregnant rats and 3 pregnant rats carrying fetuses with spina bifida aperta induced by all-trans retinoic acid (Sigma; 4% [wt/vol] in olive oil; 140 mg/kg body weight by gavage) at pregnant...
ORGANISM(S): Rattus Norvegicus (rat) 
2022-10-14 | PXD023775 | Pride
Lc-msms Rat Serum exosome Label free 
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Proteomicsthe proteomic profiles of single-sex infected female worms and bisexual infected mature female worms of Schistosoma japonicum at 18, 21, 23 and 25 days post infection
Revealing the reproductive mechanism of schistosomes will help to control this disease. In this study, the proteomic profiles of single-sex infected female (SF) worms and bisexual infected mature female (MF) worms of Schistosoma japonicum at 18, 21, 23 and 25 days post infection (dpi) were identified wi...
ORGANISM(S): Schistosoma Japonicum (blood Fluke) 
2024-01-26 | PXD030834 | Pride
Bisexual infected mature female Single-sex infected female Lc-ms/ms Itraq Schistosoma japonicum 
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ProteomicsPhosphoproteomic analysis of signaling downstream of p85β
p85β is a regulatory subunit of phosphatidylinositol 3-kinase. The signaling mechanism of p85β is poorly understood. Quantitative mass spectrometry-based phosphoproteomic analysis was therefore performed to reveal proteins with an altered phosphorylation status upon PIK3R2 depletion in ovarian cancer ce...
ORGANISM(S): Homo Sapiens (human) 
2020-05-08 | PXD018449 | Pride
Phosphoproteomics Pi3k P85 
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ProteomicsOTUD5 complex mass spectrometry
DUBs are involved in various pathways and signalling networks by pairing with E3 ubiquitin ligases in protein complexes. In order to test whether OTUD5 associates with an E3 ubiquitin ligase to regulate cell proliferation, the stable Flag-OTUD5/Hep3B cell line was established by transfecting Hep3B cel...
ORGANISM(S): Homo Sapiens (human) 
2020-09-11 | PXD019907 | Pride
Protein complex Otud5 
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UnknownClinical Evidence and Potential Mechanisms of Complementary Treatment of Ling Gui Zhu Gan Formula for the Management of Serum Lipids and Obesity.
Not available
S-EPMC9110158 | biostudies-literature
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