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ProteomicsDarapladib, an inhibitor of Lp-PLA2, sensitises cancer cells to ferroptosis by remodelling lipid metabolism
Arachidonic and adrenic acids in the membrane play key roles in ferroptosis, but how these fatty acids are manipulated in cells is largely unknown. Here, we reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular phospholipid metabolism and contributes to ferroptosis res...
ORGANISM(S): Homo Sapiens (human) 
2023-10-24 | PXD044002 | Pride
Lp-pla2 Cancer cell Lc-ms/ms Lipidomics 
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TranscriptomicsGene expression profile of FOXM1 with Doxorubicin in MDA-MB-231 breast cancer cells
Transcription factors (TFs) play a crucial role in diverse cellular physiology by controlling down-stream target genes. It has been well recognized that TFs are attractive target for treating human cancer since transcriptional activity or gene expression level of TFs can be directly modulated. To ex...
ORGANISM(S): Homo sapiens 
2012-05-14 | E-GEOD-25741 | biostudies-arrayexpress
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TranscriptomicsGene expression profiling of melanoma brain metastases and matched extracranial metastases
An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between bra...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-50493 | biostudies-arrayexpress
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TranscriptomicsSomatic copy number variation profiling in matched brain and extracranial metastases of melanoma
An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between bra...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-50495 | biostudies-arrayexpress
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