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MetabolomicsNavigating natural variation in herbivory-induced secondary metabolism in coyote tobacco populations using MS/MS structural analysis
Natural variation can be extremely useful in unraveling the determinants of phenotypic trait evolution but has rarely been analyzed with unbiased metabolic profiling to understand how its effects are organized at the level of biochemical pathways. Native populations of Nicotiana attenuata, a wild tob...
2015-06-15 | MTBLS203 | MetaboLights
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MetabolomicsIlluminating a plant’s tissue-specific metabolic diversity using computational metabolomics and information theory
While cross-tissue metabolite variations are increasingly regarded as important readouts of tissue-level gene regulatory processes, these have rarely been explored by non-targeted metabolomics. Here we explore tissue-level metabolic specialization in Nicotiana attenuata, an ecological model with rich...
2016-12-02 | MTBLS335 | MetaboLights
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Proteomics,MultiomicsXAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence
XAB2 is a multi-functional protein participating processes including transcription, splicing, DNA repair and mRNA export. Here we report POLR2A as a major target gene down-regulated after XAB2 depletion. XAB2 depletion led to severe splicing defects of POLR2A with significant intron retention. Such de...
ORGANISM(S): Homo Sapiens (human) 
2019-11-13 | PXD012552 | Pride
Xab2 Polr2a Hela cell 
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UnknownIdentification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19.
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S-EPMC9515335 | biostudies-literature
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UnknownAn SPRI beads-based DNA purification strategy for flexibility and cost-effectiveness.
Not available
S-EPMC10022144 | biostudies-literature
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UnknownComplete Genome Sequence of Brevibacillus laterosporus Bl-zj, an Algicidal Bacterium Isolated from Soil.
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S-EPMC6658680 | biostudies-literature
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UnknownLung Microbiota and Pulmonary Inflammatory Cytokines Expression Vary in Children With Tracheomalacia and Adenoviral or Mycoplasma pneumoniae Pneumonia.
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S-EPMC6611399 | biostudies-literature
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UnknownHandgrip Strength-Related Factors Affecting Health Outcomes in Young Adults: Association with Cardiorespiratory Fitness.
Not available
S-EPMC8084643 | biostudies-literature
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UnknownIntegrating pathology, chromosomal instability and mutations for risk stratification in early-stage endometrioid endometrial carcinoma.
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S-EPMC7583263 | biostudies-literature
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UnknownMicroRNA-125a-3p is involved in early behavioral disorders in stroke-afflicted rats through the regulation of Cadm2.
Not available
S-EPMC5716446 | biostudies-literature
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