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ProteomicsIdentification of a novel class of cytotoxic granules as origin of supramolecular attack particles in T lymphocytes
Cytotoxic T lymphocytes (CTL) kill malignant and infected cells via cytotoxic proteins such as granzyme B (GzmB) that are released into the immunological synapse in the form of ~110 nm supramolecular attack particles (SMAPs). However, it is not known where SMAPs are stored in the cell and how they ar...
ORGANISM(S): Mus Musculus (mouse) 
2022-04-04 | PXD025055 | Pride
Correlative light and electron microscopy Immunological synapse Cytotoxic granules Total internal reflection fluorescence microscopy Multi core granules Proteomics Single core granules Exocytosis Supramolecular attack particles Snare proteins 
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ProteomicsGermline maintenance through the multifaceted activities of GLH/Vasa in Caenorhabditis elegans P granules
Vasa is a highly conserved member of the ATP-dependent DEAD box helicase family, a multipotency factor, and a critical component for the specification and maintenance of the germline. Its homologs have been shown to regulate translation, small RNA amplification, and serve as a molecular solvent for s...
ORGANISM(S): Caenorhabditis Elegans 
2019-06-07 | PXD014135 | Pride
Vasa C. elegans Glh-1 coip Glh-1 
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ProteomicsQuantitative chemoproteomic identification of lysine carboxylation in proteins
Carbon dioxide is an abundant biological gas that drives adaptive physiological responses within organisms from all domains. The basic biochemical mechanisms by which proteins serve as sensors of CO2 are, therefore, of great interest. CO2 is a potent electrophilic, and thus one way it can modulate pr...
ORGANISM(S): Escherichia Coli Synechocystis Sp. 
2023-09-09 | PXD031976 | Pride
Chemoproteomics Lysine carboxylation Co2 Homocitrulline 
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