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ProteomicsThe Trans-omics Landscape of COVID-19
System-wide molecular characteristics of COVID-19, especially in those patients without comorbidities, have not been fully investigated. We compared extensive molecular profiles of blood samples from 231 COVID-19 patients, ranging from asymptomatic to critically ill, importantly excluding those with a...
ORGANISM(S): Homo Sapiens (human) 
2021-03-12 | PXD024674 | Pride
Covid-19 
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ProteomicsCovalent Inhibition of Pro-Apoptotic BAX
BCL-2-associated X protein (BAX) is a promising therapeutic target for activating or restraining apoptosis in dis...
...iochemical and structural analyses revealed that CBI1 can inhibit BAX by a dual mechanism of action: conformational constraint and competitive blockade of lipidation. Hydrogen deuterium exchange mass spectrometry (HDX MS) showed that CBI1 derivatization of BAX C126 reversed the conformational changes caused by the auto-activating mutant F116A These data inform a pharmacologic strategy for blocking apoptosis in diseases of unwanted cell death by covalent targeting of BAX C126.
ORGANISM(S): Homo Sapiens (human) 
2024-01-19 | PXD040917 | Pride
Bax  hdx-ms  hydrogen/deuterium exchange mass spectrometry  covalent inhibitor covalent inhibitor hdx-ms Bax hydrogen/deuterium exchange mass spectrometry 
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MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231...
2021-10-06 | MTBLS2542 | MetaboLights
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ProteomicsA liquid chromatography-tandem mass spectrometry analysis of endogenous TWIST1 immunoprecipitates in the LSCs from MLL-AF9+ AML mice
We performed a liquid chromatography-tandem mass spectrometry analysis of endogenous TWIST1 immunoprecipitates in the LSCs isolated from MLL-AF9-driven AML mice
ORGANISM(S): Mus Musculus 
2022-10-09 | PXD037217 |
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