Sort   by:  
 Page size 
0
Recent genetic evidence implicates the serine/threonine kinase cyclin G-associated kinase (GAK) as a ...
...ged dendritic spines and we identify the spine associated protein Sipa1L1 (or SPAR) as a GAK target, which may contribute to this effect. Our results reveal novel functions of GAK in neurons.
ORGANISM(S): Mus Musculus (mouse) 
2019-01-07 | PXD011319 | Pride
0
Granulocyte-colony stimulating factor (G-CSF) is used to boost granulocyte counts in immunocompromised patients, but its effects on the immune system may be counter productive. We tested the hypothesis that G-CSF mobilized peripheral blood stem cell (PBSC) products are immunologically down regulated ba...
ORGANISM(S): Homo sapiens 
0
Diabetic nephropathy (DN) is a major cause of end-stage renal disease and has limited therapeutic options to prevent its progression. To identify novel therapeutic strategies, protective factors for DN were studied using proteomics on glomeruli from 50-year medalists (individuals with extreme duratio...
ORGANISM(S): Homo Sapiens (human) 
2017-05-02 | PXD006339 | Pride
0
...usal relationships are poorly defined. Importantly, functional compensation for developmental defects may mask increased risk of arrhythmia in adults. Here, we deleted 9 amino acids (Δ9) within a highly conserved A-band region of titin, a giant protein that serves as a molecular spring in cardiomyocy...
ORGANISM(S): Danio Rerio (zebrafish) (brachydanio Rerio) 
2024-08-09 | PXD038300 | Pride
0
A major challenge to the study of tumor DNA copy number (CN) in clinical specimens is the lack of appropriate...
...en tumor samples. Since the MIP probes require only a small (~40 bp) target binding site, we reasoned they may be well suited to assess FFPE samples. In this study, we successfully applied MIP technology with a panel of 50,000 markers to CN determination in FFPE samples. Using an input of 37 ng genomic DNA, we demonstrated high quali ty CN data with MIP technology from 93 FFPE samples from seven diverse collections. We found that the performance of FFPE DNA for CN determination was comparable to that of DNA obtained fro...
ORGANISM(S): Homo sapiens 
0
A major challenge to the study of tumor DNA copy number (CN) in clinical specimens is the lack of appropriate...
...en tumor samples. Since the MIP probes require only a small (~40 bp) target binding site, we reasoned they may be well suited to assess FFPE samples. In this study, we successfully applied MIP technology with a panel of 50,000 markers to CN determination in FFPE samples. Using an input of 37 ng genomic DNA, we demonstrated high quality CN data with MIP technology from 93 FFPE samples from seven diverse collections. We found that the performance of FFPE DNA for CN determination was comparable to that of DNA obtained from...
ORGANISM(S): Homo sapiens 
0
Esophageal adenocarcinomas (EACs) are associated with dismal prognosis. Deciphering the evolutionary histories of this disease may shed light on therapeutically tractable targets and reveal changing mutational processes during the disease course and following neoadjuvant chemotherapy (NAC). We exome se...
0
A major challenge to the study of tumor DNA copy number (CN) in clinical specimens is the lack of appropriate...
...en tumor samples. Since the MIP probes require only a small (~40 bp) target binding site, we reasoned they may be well suited to assess FFPE samples. In this study, we successfully applied MIP technology with a panel of 50,000 markers to CN determination in FFPE samples. Using an input of 37 ng genomic DNA, we demonstrated high quali ty CN data with MIP technology from 93 FFPE samples from seven diverse collections. We found that the performance of FFPE DNA for CN determination was comparable to that of DNA obtained fro...
ORGANISM(S): Homo sapiens 
0
: A major challenge to the study of tumor DNA copy number (CN) in clinical specimens is the lack of appropriate...
...en tumor samples. Since the MIP probes require only a small (~40 bp) target binding site, we reasoned they may be well suited to assess FFPE samples. In this study, we successfully applied MIP technology with a panel of 50,000 markers to CN determination in FFPE samples. Using an input of 37 ng genomic DNA, we demonstrated high quali ty CN data with MIP technology from 93 FFPE samples from seven diverse collections. We found that the performance of FFPE DNA for CN determination was comparable to that of DNA ob...
ORGANISM(S): Homo sapiens 
0
A major challenge to the study of tumor DNA copy number (CN) in clinical specimens is the lack of appropriate...
...en tumor samples. Since the MIP probes require only a small (~40 bp) target binding site, we reasoned they may be well suited to assess FFPE samples. In this study, we successfully applied MIP technology with a panel of 50,000 markers to CN determination in FFPE samples. Using an input of 37 ng genomic DNA, we demonstrated high quali ty CN data with MIP technology from 93 FFPE samples from seven diverse collections. We found that the performance of FFPE DNA for CN determination was comparable to that of DNA obtained fro...
ORGANISM(S): Homo sapiens 
Sort   by:  
 Page size 

Search Feedback