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ProteomicsUbiquitin-mediated modulation of necroptotic effector MLKL
We aimed to identify lysine (K) residues that are endogenously ubiquitylated upon TNF-induced necroptosis. To this end, we used a quantitative mass spectrometry-based approach. Briefly, MDFs were treated with TSZ or left untreated and protein lysates were digested with trypsin into peptides. Ubiquity...
ORGANISM(S): Mus Musculus (mouse) 
2021-04-13 | PXD018857 | Pride
Ubiquitin Mlkl Mouse Msms Tmt Cancer 
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ProteomicsIlluminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates
HEK293 Flp-In cells were transfected transiently with various SLC22A10 orthologs, including human, chimpanzee, and the mutations to proline or leucine at position 220. After 72 hours of transfection, cell pellets were collected. The quantification was performed on both HEK293 cells and HEK293cells ex...
ORGANISM(S): Homo Sapiens (human) 
2024-04-09 | PXD047102 | Pride
Hek293 Lc-ms/ms Slc22a10 
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UnknownUbiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Not available
S-EPMC8184782 | biostudies-literature
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UnknownImpact of ancestry and common genetic variants on QT interval in African Americans.
Not available
S-EPMC3568265 | biostudies-literature
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Genomics,MultiomicsFramingham Cohort
...f death and serious illness in the United States. In 1948, the Framingham Heart Study (FHS) -- under the direction of the National Heart Institute (now known as the National Heart, Lung, and Blood Institute, NHLBI) -- embarked on a novel and ambitious project in health research. At the time, little w...
phs000007.v17.p6 | EGA
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GenomicsNHLBI Jackson Heart Study Candidate Gene Association Resource (CARe)

The Jackson Heart Study (JHS) is a large, community-based, observational study whose participants were recruited from urban and rural areas of the three counties (Hinds, Madison and Rankin) that make up the Jackson, Mississippi, metropolitan statistical area (MSA). Participants were enrolled fr...

phs000286.v2.p1 | EGA
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Genomics,MultiomicsNHLBI Atherosclerosis Risk in Communities (ARIC) Candidate Gene Association Resource (CARe)
...(NHLBI), is a prospective epidemiologic study conducted in four U.S. communities. The four communities are Forsyth County, NC; Jackson, MS; the northwest suburbs of Minneapolis, MN; and Washington County, MD. ARIC is designed to investigate the etiology and natural history of atherosclerosis, the et...
phs000280.v1.p1 | EGA
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Genomics,MultiomicsThe Atherosclerosis Risk in Communities (ARIC) Study
...NHLBI), is a prospective epidemiologic study conducted in four U.S. communities. The four communities are Forsyth County, NC; Jackson, MS; the northwest suburbs of Minneapolis, MN; and Washington County, MD. ARIC is designed to investigate the etiology and natural history of atherosclerosis, the...
phs000090.v1.p1 | EGA
0
UnknownExploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise.
Not available
S-EPMC7222458 | biostudies-literature
0
UnknownThe Analysis of Teaching of Medical Schools (AToMS) survey: an analysis of 47,258 timetabled teaching events in 25 UK medical schools relating to timing, duration, teaching formats, teaching content, and problem-based learning.
Not available
S-EPMC7222546 | biostudies-literature
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