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ProteomicsTumor suppressor TAp73 is required to maintain pluripotency of cancer stem cells
Cancer stem cells (CSCs) are resistant to conventional chemotherapy and are hence responsible for cancer relapse. Pluripotency is a characteristic of CSCs which allows them to rapidly proliferate while maintaining the ability to differentiate into various lineages. We found that TAp73, but not its ho...
ORGANISM(S): Homo Sapiens (human) 
2019-03-05 | PXD005407 | Pride
Stem cells P73 
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ProteomicsEnhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome
The impact of healthy aging on molecular programming of immune cells is poorly understood. Here, we report comprehensive characterization of healthy aging in human classical monocytes, with a focus on epigenomic, transcriptomic, and proteomic alterations, as well as the corresponding proteomic and me...
ORGANISM(S): Homo Sapiens (human) 
2022-02-16 | PXD021821 | Pride
Human Human  monocyte  aging monocyte aging 
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Genomics,MultiomicsFramingham Cohort

Startup of Framingham Heart Study. Cardiovascular disease (CVD) is the leading cause of death and serious illness in the United States. In 1948, the Framingham Heart Study (FHS) -- under the direction of the National Heart Institute (now known as the National Heart, Lung, and Blood Institut...

phs000007.v17.p6 | EGA
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GenomicsThe Genetic Analysis of multiple sclerosis
We created these data in order to identify genetic variants associated with increased susceptibility to multiple sclerosis. Cases from many parts of the world were genotyped with the Illumina 660 chip along with Swedish controls. In our analysis we also used control data from the WTCCC2 common UK con...
EGAS00000000101 | EGA
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GenomicsMS
WTCCC2 project Multiple Sclerosis (MS) samples
EGAD00000000120 | EGA
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Genomicsena-DATASET-dkfz_b062-21-02-2018-14:40:33:479-591 - samples
This dataset contains whole exome sequencing data from 24 patients. The Agilent SureSelect Human All Exon 50-Mb target enrichment kit was used to capture all human exons for deep sequencing. For each patient a tumour and control sample has been sequenced on a Illumina HiSeq2000 instrument in paired-e...
EGAD00001003973 | EGA
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Genomicsena-DATASET-dkfz_b062-23-02-2018-16:41:10:412-192 - samples
This dataset contains ChIP sequencing data from 24 patients. ChIP of 5–10 mg flash-frozen primary ependymoma tumour was performed using 5 mg H3K27ac antibody per ChIP experiment. The enriched DNA has been sequenced on a Illumina HiSeq2000 instrument in paired-end mode. Up to two lanes per sample...
EGAD00001003979 | EGA
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Genomics40a8fdd0-0c02-480d-b938-15d6a8c2ecbc - samples
This dataset contains chromosomal conformation capture data from fourteen samples (eleven tumor samples and three tumor derived cell lines). Libraries were prepared using the Illumina TruSeq LT sequencing adaptors. Sequencing was performed on the HiSeq X or NovaSeq platforms resulting in 28 FASTQ fil...
EGAD00001008801 | EGA
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Genomicsena-DATASET-dkfz_b062-16-02-2018-17:18:40:151-347 - samples
This dataset conatains RNA sequencing data from 24 patients. Up to two lanes per tumour sample have been seqeunced on a Illumina HiSeq2000 instrument in paired-end mode resulting in 58 Fastq files.
EGAD00001003966 | EGA
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Genomicsena-DATASET-dkfz_b062-31-01-2018-17:04:38:652-360 - samples
This dataset contains whole genome sequencing data from 24 patients. For each patient a tumour and control sample has been sequenced on a Illumina HiSeq2000 instrument in paired-end mode. Up to three lanes per sample have been sequenced resulting in 112 Fastq files.
EGAD00001003940 | EGA
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