Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate essential cellular activities including protein quality control, calcium flux, and sterol homeostasis. At least 25 different, transmembrane domain (TMD)-containing E3s are predicted to be ER-localised, but for most t...
The Ocular Hypertension Treatment Study (OHTS) is an National Eye Institute-sponsored multi-cent... ...ypertension between 40 and 80 years old were enrolled in the study. In addition to ocular hypertension, subjects in the OHTS were required to have normal optic nerve appearance as determined by the OHTS Optic Disc Reading Center and normal and reliable visual field tests...
...ramingham Heart Study. Cardiovascular disease (CVD) is the leading cause of death and serious illn... ...e (now known as the National Heart, Lung, and Blood Institute, NHLBI) -- embarked on a novel and ambitious project in heal...
Cholangiocarcinoma is a cancer of the hepatic bile ducts that is typically detected at a stage too advanced for resection. Additionally, chemotherapy is of limited efficacy, hence, novel therapeutic approaches are urgently required, including targeting of the cancer stroma. A macrophage-derived signa...
