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ProteomicsEpstein-Barr Virus Induced One-Carbon Metabolism Drives B-Cell Transformation
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B-cell lymphomas. How EBV remodels metabolic pathways to support rapid B-cell outgrowth remains largely unknown. To gain insights, primary human B-cells were profiled by tandem-mass-tag based proteomics at rest and at 9 time points...
ORGANISM(S): Homo Sapiens (human) Epstein-barr Virus Strain P3hr-1 
2019-06-28 | PXD013034 | Pride
Quantitative proteomics Epstein-barr virus Tandem mass tag One-carbon metabolism Host-pathogen interaction Herpesvirus 
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ProteomicsProteomics analysis of regulation by Bmal1 and physiological time-restricted feeding
To define regulation of tissue proteomes by Bmal1, daily feeding rhythm, and the interaction, we employed Bmal1-stopFL mice, which do n...
...ine wherein both hepatocyte and skeletal muscle Bmal1 were reconstituted (Liver+Muscle-RE), i.e., rescued (Smith, Koronowski et al. 2023). This approach had the benefit of analyzing liver and muscle from the same mice but comes with the qualification that the abundance of some proteins may be influenced by Bmal1 function in the other tissue, or by a synergistic effec...
ORGANISM(S): Mus Musculus (mouse) 
2024-01-26 | PXD040362 | Pride
Liver Muscle Circadian rhythm Clock Bmal1 
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ProteomicsBtuB TonB-dependent transporters and BtuG surface lipoproteins form stable complexes for vitamin B12 uptake in gut Bacteroides.
Vitamin B12 (cobalamin) is the most complex vitamin and essential for many human gut microbes. However, cobalamin is synthesized only by a limited number of bacteria, making many gut microbes dependent on scavenging to meet their cobalamin requirements. Since bacterial densities in the gut are extrem...
ORGANISM(S): Bacteroides Thetaiotaomicron Bacteria 
2023-10-18 | PXD038230 | Pride
B12 Fusion-lumos Gut Bacteria Orbitrap Bacteroides 
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MetabolomicsCharacterizing the intrauterine environment via untargeted metabolomics profiling of maternal blood collected during pregnancy (PETALS Cohort)
...ort PI Assiamira Ferrara (Assiamira.Ferrara@kp.org) and Co-I Yeyi Zhu (yeyi.zhu@kp.org) for questions related to the subject characteristics and outcomes. This research was supported by the Environmental influ...
...CHO Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Ma...
ORGANISM(S): Human Homo Sapiens 
2023-01-12 | ST002439 | MetabolomicsWorkbench
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MetabolomicsCharacterizing the intrauterine environment via untargeted metabolomics profiling of maternal blood collected during pregnancy (ARCH Cohort)
The ARCH Cohort is a pregnancy cohort of approximately 1,000 women recruited at the first prenatal visit largely in Lansing, MI between 2008 and 2016. Blood was collected when possible at the onset of prenatal care and at ...
...Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Catellier D; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at C...
ORGANISM(S): Human Homo Sapiens 
2023-01-17 | ST002443 | MetabolomicsWorkbench
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MetabolomicsImpacts of interactions between environmental chemical exposures and diet on gut microbiota and microbiota-derived metabolites in mothers and children (MARCH Cohort)
MARCH is a prospective population based pregnancy cohort that recruited pregnant participants from 2017-2023 from 11 sites withi...
...Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Catellier D; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539
ORGANISM(S): Human Homo Sapiens 
2023-01-12 | ST002441 | MetabolomicsWorkbench
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MetabolomicsCharacterizing the intrauterine environment via untargeted metabolomics profiling of maternal blood collected during pregnancy (Atlanta ECHO Cohort)
The Atlanta ECHO Cohort is comprised of African American mother-child dyads who reside in the greater metropolitan Atlanta area. Enrollment begins during pregnancy from prenatal care clinics affiliated with two metro hospital systems....
...Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Catellier D; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539
ORGANISM(S): Human Homo Sapiens 
2022-11-14 | ST002351 | MetabolomicsWorkbench
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MetabolomicsCharacterizing the intrauterine environment via untargeted metabolomics profiling of maternal blood collected during pregnancy (Healthy Start Cohort)-Part 2
Healthy Start is a prospective, pre-birth cohort study that recruited pregnant participants from outpatient prenatal clinics at th...
...Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Catellier D; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539
ORGANISM(S): Human Homo Sapiens 
2022-09-12 | ST002300 | MetabolomicsWorkbench
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MetabolomicsPerfluoroalkyl Compounds and Child Metabolic Health - Healthy Start Cohort
Healthy Start is a prospective, pre-birth cohort study that recruited pregnant participants from outpatient prenatal clinics at th...
...Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Parker CB; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539
ORGANISM(S): Human Homo Sapiens 
2021-12-22 | ST002049 | MetabolomicsWorkbench
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MetabolomicsCharacterizing the intrauterine environment via untargeted metabolomics profiling of maternal blood collected during pregnancy (Healthy Start Cohort)-Part 1
Healthy Start is a prospective, pre-birth cohort study that recruited pregnant participants from outpatient prenatal clinics at th...
...Program Collaborators: ECHO Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK; U2C OD023375 ECHO Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Catellier D; U24 OD023382 North Carolina Human Health Exposure Analysis Resource Hub: Research Triangle Institute: Fennell T, University of North Carolina at Chapel Hill: Sumner S, University of North Carolina at Charlotte: Du X; U2C ES030857 Human Health Exposure Analysis Resource Coordinating Center: Westat, Inc., Rockville, Maryland: O’Brien B; U24 ES026539
ORGANISM(S): Human Homo Sapiens 
2022-09-08 | ST002299 | MetabolomicsWorkbench
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