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MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
...ways in myeloid cell functions during the development of renal fibrosis remains understudied. In our study, we initially reanalyzed single-cell RNA sequencing data of renal myeloid cells from Dr. Denby’s group and observed an increased glycolytic pathway in myeloid cells that are critical for renal i...
2024-03-12 | MTBLS8278 | MetaboLights
0
Genomicsena-DATASET-BGI-18-06-2015-05:57:10:511-19 - samples
We sequenced 205 patients who were suffering NSCLC with Exome sequencing method.
EGAD00001001398 | EGA
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Genomicsena-DATASET-BGI-18-06-2015-04:55:13:301-17 - samples
We sequenced 292 patients who were suffering NSCLC with Whole genome sequencing or Exome sequencing method.
EGAD00001001397 | EGA
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GenomicsBGI Data Access Committee
Data Access Committee EGAC00001000177
EGAC00001000177 | EGA
0
GenomicsFrequent alterations in cytoskeleton remodeling genes in primary and metastatic Chinese lung adenocarcinomas
...re furthermore significantly enriched in tumours from patients harbouring metastases. Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis. Our study...
EGAS00001000982 | EGA
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MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis
...activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remains unexplored in renal fibrosis. Upon reanalyzing the single-cell sequencing data from Dr. Humphreys' lab, we noticed an upregulation of glycolysis, gluconeogenesis, and TGFβ signaling pathway in myofibroblasts from fib...
2024-03-12 | MTBLS8281 | MetaboLights
1K
OtherBGI
Organisation EGAO00000000208
EGAO00000000208 | EGA
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