{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Roberts NT"],"funding":["Wisconsin Alumni Research Foundation","NCATS NIH HHS","NIDDK NIH HHS","Institute for Clinical and Translational Research, University of Wisconsin, Madison","University of Wisconsin-Madison","National Institutes of Health","GE Healthcare","Office of the Vice Chancellor for Research and Innovation"],"pagination":["2186-2203"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10139739"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["89(6)"],"pubmed_abstract":["<h4>Purpose</h4>Quantitative volumetric T<sub>1</sub> mapping in the liver has the potential to aid in the detection, diagnosis, and quantification of liver fibrosis, inflammation, and spatially resolved liver function. However, accurate measurement of hepatic T<sub>1</sub> is confounded by the presence of fat and inhomogeneous B1+$$ {B}_1^{+} $$ excitation. Furthermore, scan time constraints related to respiratory motion require tradeoffs of reduced volumetric coverage and/or increased acquisition time. This work presents a novel 3D acquisition and estimation method for confounder-corrected T<sub>1</sub> measurement over the entire liver within a single breath-hold through simultaneous estimation of T<sub>1</sub> , fat and B1+$$ {B}_1^{+} $$ .<h4>Theory and methods</h4>The proposed method combines chemical shift encoded MRI and variable flip angle MRI with a B1+$$ {B}_1^{+} $$ mapping technique to enable confounder-corrected T<sub>1</sub> mapping. The method was evaluated theoretically and demonstrated in both phantom and in vivo acquisitions at 1.5 and 3.0T. At 1.5T, the method was evaluated both pre- and post- contrast enhancement in healthy volunteers.<h4>Results</h4>The proposed method demonstrated excellent linear agreement with reference inversion-recovery spin-echo based T<sub>1</sub> in phantom acquisitions at both 1.5 and 3.0T, with minimal bias (5.2 and 45 ms, respectively) over T<sub>1</sub> ranging from 200-1200 ms. In vivo results were in general agreement with reference saturation-recovery based 2D T<sub>1</sub> maps (SMART<sub>1</sub> Map, GE Healthcare).<h4>Conclusion</h4>The proposed 3D T<sub>1</sub> mapping method accounts for fat and B1+$$ {B}_1^{+} $$ confounders through simultaneous estimation of T<sub>1</sub> , B1+$$ {B}_1^{+} $$ , PDFF and R2*$$ {R}_2^{\\ast } $$ . It demonstrates strong linear agreement with reference T<sub>1</sub> measurements, with low bias and high precision, and can achieve full liver coverage in a single breath-hold."],"journal":["Magnetic resonance in medicine"],"pubmed_title":["Confounder-corrected T<sub>1</sub> mapping in the liver through simultaneous estimation of T<sub>1</sub> , PDFF, R2* , and B1+ in a single breath-hold acquisition."],"pmcid":["PMC10139739"],"funding_grant_id":["R01 DK088925","UL1 TR002373","UL1TR002373"],"pubmed_authors":["Muslu Y","Tamada D","Hernando D","Roberts NT","Reeder SB"],"additional_accession":[]},"is_claimable":false,"name":"Confounder-corrected T<sub>1</sub> mapping in the liver through simultaneous estimation of T<sub>1</sub> , PDFF, R2* , and B1+ in a single breath-hold acquisition.","description":"<h4>Purpose</h4>Quantitative volumetric T<sub>1</sub> mapping in the liver has the potential to aid in the detection, diagnosis, and quantification of liver fibrosis, inflammation, and spatially resolved liver function. However, accurate measurement of hepatic T<sub>1</sub> is confounded by the presence of fat and inhomogeneous B1+$$ {B}_1^{+} $$ excitation. Furthermore, scan time constraints related to respiratory motion require tradeoffs of reduced volumetric coverage and/or increased acquisition time. This work presents a novel 3D acquisition and estimation method for confounder-corrected T<sub>1</sub> measurement over the entire liver within a single breath-hold through simultaneous estimation of T<sub>1</sub> , fat and B1+$$ {B}_1^{+} $$ .<h4>Theory and methods</h4>The proposed method combines chemical shift encoded MRI and variable flip angle MRI with a B1+$$ {B}_1^{+} $$ mapping technique to enable confounder-corrected T<sub>1</sub> mapping. The method was evaluated theoretically and demonstrated in both phantom and in vivo acquisitions at 1.5 and 3.0T. At 1.5T, the method was evaluated both pre- and post- contrast enhancement in healthy volunteers.<h4>Results</h4>The proposed method demonstrated excellent linear agreement with reference inversion-recovery spin-echo based T<sub>1</sub> in phantom acquisitions at both 1.5 and 3.0T, with minimal bias (5.2 and 45 ms, respectively) over T<sub>1</sub> ranging from 200-1200 ms. In vivo results were in general agreement with reference saturation-recovery based 2D T<sub>1</sub> maps (SMART<sub>1</sub> Map, GE Healthcare).<h4>Conclusion</h4>The proposed 3D T<sub>1</sub> mapping method accounts for fat and B1+$$ {B}_1^{+} $$ confounders through simultaneous estimation of T<sub>1</sub> , B1+$$ {B}_1^{+} $$ , PDFF and R2*$$ {R}_2^{\\ast } $$ . It demonstrates strong linear agreement with reference T<sub>1</sub> measurements, with low bias and high precision, and can achieve full liver coverage in a single breath-hold.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2024-11-10T03:48:10.728Z","creation":"2024-11-10T03:48:10.728Z"},"accession":"S-EPMC10139739","cross_references":{"pubmed":["36656152"],"doi":["10.1002/mrm.29590"]}}