{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Purroy F"],"funding":["Instituto de Salud Carlos III","Agència de Gestió d&apos;Ajuts Universitaris i de Recerca","Ministerio de Ciencia e Innovación"],"pagination":["13706"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10444771"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["While TIA patients have transient symptoms, they should not be underestimated, as they could have an underlying pathology that may lead to a subsequent stroke: stroke recurrence (SR). Previously, it has been described the involvement of lipids in different vascular diseases. The aim of the current study was to perform a lipidomic analysis to identify differences in the lipidomic profile between patients with SR and patients without. Untargeted lipidomic analysis was performed in plasma samples of 460 consecutive TIA patients recruited < 24 h after the onset of symptoms. 37 (8%) patients suffered SR at 90 days. Lipidomic profiling disclosed 7 lipid species differentially expressed between groups: 5 triacylglycerides (TG), 1 diacylglyceride (DG), and 1 alkenyl-PE (plasmalogen) [specifically, TG(56:1), TG(63:0), TG(58:2), TG(50:5), TG(53:7, DG(38:5)) and PE(P-18:0/18:2)]. 6 of these 7 lipid species belonged to the glycerolipid family and a plasmalogen, pointing to bioenergetics pathways, as well as oxidative stress response. In this context, it was proposed the PE(P-18:0/18:2) as potential biomarker of SR condition.The observed changes in lipid patterns suggest pathophysiological mechanisms associated with lipid droplets metabolism and antioxidant protection that is translated to plasma level as consequence of a more intensive or high-risk ischemic condition related to SR."],"journal":["Scientific reports"],"pubmed_title":["Lipidomic signature of stroke recurrence after transient ischemic attack."],"pmcid":["PMC10444771"],"funding_grant_id":["RTI2018-099200-B-I00","PI17-01725","2017 SGR 696","2017 SGR 1628"],"pubmed_authors":["Ois A","Roquer J","Rodriguez-Campello A","Jove M","Pamplona R","Arque G","Portero M","Mauri-Capdevila G","Purroy F","Sol J"],"additional_accession":[]},"is_claimable":false,"name":"Lipidomic signature of stroke recurrence after transient ischemic attack.","description":"While TIA patients have transient symptoms, they should not be underestimated, as they could have an underlying pathology that may lead to a subsequent stroke: stroke recurrence (SR). Previously, it has been described the involvement of lipids in different vascular diseases. The aim of the current study was to perform a lipidomic analysis to identify differences in the lipidomic profile between patients with SR and patients without. Untargeted lipidomic analysis was performed in plasma samples of 460 consecutive TIA patients recruited < 24 h after the onset of symptoms. 37 (8%) patients suffered SR at 90 days. Lipidomic profiling disclosed 7 lipid species differentially expressed between groups: 5 triacylglycerides (TG), 1 diacylglyceride (DG), and 1 alkenyl-PE (plasmalogen) [specifically, TG(56:1), TG(63:0), TG(58:2), TG(50:5), TG(53:7, DG(38:5)) and PE(P-18:0/18:2)]. 6 of these 7 lipid species belonged to the glycerolipid family and a plasmalogen, pointing to bioenergetics pathways, as well as oxidative stress response. In this context, it was proposed the PE(P-18:0/18:2) as potential biomarker of SR condition.The observed changes in lipid patterns suggest pathophysiological mechanisms associated with lipid droplets metabolism and antioxidant protection that is translated to plasma level as consequence of a more intensive or high-risk ischemic condition related to SR.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2024-11-08T12:44:46.137Z","creation":"2024-11-08T12:44:46.137Z"},"accession":"S-EPMC10444771","cross_references":{"pubmed":["37607967"],"doi":["10.1038/s41598-023-40838-7"]}}