{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(4)"],"submitter":["Castillo JA"],"pubmed_abstract":["<h4>Background</h4>Respiratory multimorbidities are linked to asthma, such as allergic rhinitis (AR) with early allergic asthma and chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) with late nonallergic asthma.<h4>Objective</h4>Our aim was to investigate the association of asthma severity and control with specific upper airway phenotypes.<h4>Method</h4>Patients with asthma were prospectively recruited from 23 pulmonology and ear, nose, and throat clinics. Asthma severity and control, as well as upper airway comorbidities (AR and non-AR [NAR], CRSwNP, and CRS without nasal polyps [CRSsNP]) were assessed according to international consensus guidelines definitions.<h4>Results</h4>A total of 492 asthmatic patients were included. Half of the asthmatic patients (49.6%) had associated rhinitis (37.0% had AR and 12.6% had NAR) and 36.2% had CRS (16.7% had CRSsNP and 19.5% had CRSwNP), whereas 14.2% had no sinonasal symptoms. Most cases of AR (78%) and NAR (84%) were present in patients with mild-to-moderate asthma, whereas CRSwNP was more frequent in patients with severe asthma (35% [<i>P</i> < .001]), mainly nonatopic asthma (44% [<i>P</i> < .001]). Patients with severe asthma with CRSwNP had worse asthma control, which was correlated (<i>r</i> = 0.249 [<i>P</i> = .034]) with sinus occupancy. Multiple logistic regression analysis showed that late-onset asthma, intolerance of aspirin and/or nonsteroidal anti-inflammatory drugs, and CRSwNP were independently associated with severe asthma.<h4>Conclusion</h4>Severe asthma is associated with CRSwNP, with sinus occupancy affecting asthma control. This study has identified 2 main different upper airway treatable traits, AR and CRSwNP, which need further evaluation to improve management and control of patients with asthma."],"journal":["The journal of allergy and clinical immunology. Global"],"pagination":["100134"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10510007"],"repository":["biostudies-literature"],"pubmed_title":["Chronic rhinosinusitis with nasal polyps and allergic rhinitis as different multimorbid treatable traits in asthma."],"pmcid":["PMC10510007"],"pubmed_authors":["Rodrigo G","Castillo JA","Picado C","Fernandez C","Mullol J","Julia B","Plaza V"],"additional_accession":[]},"is_claimable":false,"name":"Chronic rhinosinusitis with nasal polyps and allergic rhinitis as different multimorbid treatable traits in asthma.","description":"<h4>Background</h4>Respiratory multimorbidities are linked to asthma, such as allergic rhinitis (AR) with early allergic asthma and chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) with late nonallergic asthma.<h4>Objective</h4>Our aim was to investigate the association of asthma severity and control with specific upper airway phenotypes.<h4>Method</h4>Patients with asthma were prospectively recruited from 23 pulmonology and ear, nose, and throat clinics. Asthma severity and control, as well as upper airway comorbidities (AR and non-AR [NAR], CRSwNP, and CRS without nasal polyps [CRSsNP]) were assessed according to international consensus guidelines definitions.<h4>Results</h4>A total of 492 asthmatic patients were included. Half of the asthmatic patients (49.6%) had associated rhinitis (37.0% had AR and 12.6% had NAR) and 36.2% had CRS (16.7% had CRSsNP and 19.5% had CRSwNP), whereas 14.2% had no sinonasal symptoms. Most cases of AR (78%) and NAR (84%) were present in patients with mild-to-moderate asthma, whereas CRSwNP was more frequent in patients with severe asthma (35% [<i>P</i> < .001]), mainly nonatopic asthma (44% [<i>P</i> < .001]). Patients with severe asthma with CRSwNP had worse asthma control, which was correlated (<i>r</i> = 0.249 [<i>P</i> = .034]) with sinus occupancy. Multiple logistic regression analysis showed that late-onset asthma, intolerance of aspirin and/or nonsteroidal anti-inflammatory drugs, and CRSwNP were independently associated with severe asthma.<h4>Conclusion</h4>Severe asthma is associated with CRSwNP, with sinus occupancy affecting asthma control. This study has identified 2 main different upper airway treatable traits, AR and CRSwNP, which need further evaluation to improve management and control of patients with asthma.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2024-12-04T00:09:41.344Z","creation":"2024-12-04T00:09:41.344Z"},"accession":"S-EPMC10510007","cross_references":{"pubmed":["37781668"],"doi":["10.1016/j.jacig.2023.100134"]}}