{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Chen X"],"pubmed_abstract":["<h4>Background</h4>Sepsis is a systemic inflammatory response syndrome caused by severe infection in children, but cases of sepsis associated with human parainfluenza virus (HPIV) have been rarely reported in newborns.<h4>Case presentation</h4>We report a case of HPIV-3 positive full-term newborn admitted to the Neonatal Intensive Care Unit of Beijing Children's Hospital due to hematuria, gloomy spirit, inactivity and loss of appetite for 6 h. He had septic shock when he arrived the Accident & Emergency Department requiring immediate intubation and mechanical ventilation. Intravenous antibiotics were started. He had completely negative response to all anti-shock treatments including fluid resuscitation and vasopressor supports, and died 14 h later. Viral nucleic acid detection and metagenomic next-generation sequencing (mNGS) analyses of nasopharyngeal aspirate and blood specimens verified an HPIV-3 infection, with negative bacterial culture results. The HPIV-3 strain detected in this patient was subtyped as HPIV C3a, and two unreported amino acid mutations were found in the HN protein region.<h4>Conclusion</h4>The patient had a severe infection associated with HPIV-3, which was the cause of sepsis and septic shock. This study showed the diagnostic value of mNGS in etiological diagnosis, especially in severe neonatal case."],"journal":["Virology journal"],"pagination":["248"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10612315"],"repository":["biostudies-literature"],"pubmed_title":["A fatal case of neonatal viral sepsis caused by human parainfluenza virus type 3."],"pmcid":["PMC10612315"],"pubmed_authors":["Jin F","Wang Q","Guo Y","He W","Qi Y","Li F","Xie Z","Li Q","Chen X","Wang H","Hei M"],"additional_accession":[]},"is_claimable":false,"name":"A fatal case of neonatal viral sepsis caused by human parainfluenza virus type 3.","description":"<h4>Background</h4>Sepsis is a systemic inflammatory response syndrome caused by severe infection in children, but cases of sepsis associated with human parainfluenza virus (HPIV) have been rarely reported in newborns.<h4>Case presentation</h4>We report a case of HPIV-3 positive full-term newborn admitted to the Neonatal Intensive Care Unit of Beijing Children's Hospital due to hematuria, gloomy spirit, inactivity and loss of appetite for 6 h. He had septic shock when he arrived the Accident & Emergency Department requiring immediate intubation and mechanical ventilation. Intravenous antibiotics were started. He had completely negative response to all anti-shock treatments including fluid resuscitation and vasopressor supports, and died 14 h later. Viral nucleic acid detection and metagenomic next-generation sequencing (mNGS) analyses of nasopharyngeal aspirate and blood specimens verified an HPIV-3 infection, with negative bacterial culture results. The HPIV-3 strain detected in this patient was subtyped as HPIV C3a, and two unreported amino acid mutations were found in the HN protein region.<h4>Conclusion</h4>The patient had a severe infection associated with HPIV-3, which was the cause of sepsis and septic shock. This study showed the diagnostic value of mNGS in etiological diagnosis, especially in severe neonatal case.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2024-11-07T02:32:14.638Z","creation":"2024-11-07T02:32:14.638Z"},"accession":"S-EPMC10612315","cross_references":{"pubmed":["37891594"],"doi":["10.1186/s12985-023-02141-9"]}}