{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wothe JK"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS","American Diabetes Association","National Institutes of Health","Merck"],"pagination":["1491-1497"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8629939"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(8)"],"pubmed_abstract":["<h4>Background/objectives</h4>The effect of total pancreatectomy with islet autotransplantation (TPIAT) on bone mineral density (BMD) in patients with CP is unknown. We aimed to assess bone health in patients with CP after TPIAT.<h4>Methods</h4>We measured BMD, BMD Z-score, and bone mineral content (BMC) for total body, lumbar spine, right and left hip in 78 patients before and after TPIAT using dual-energy X-ray absorptiometry (DXA, n = 78 pre-TPIAT, n = 65 paired pre- and 12 months post-TPIAT, n = 33 paired 12 and 18 months post-TPIAT), and tested for association with clinical history including age, smoking status, and medications using paired and two-sample t-tests, linear regression, and Fisher's exact test. Laboratory measures related to bone health were also assessed.<h4>Results</h4>In the patients with pre-TPIAT DXA, 12% had low BMD (Z-score ≤ -2). BMD, BMD Z-score, and BMC all decreased from pre-to 12 months post-TPIAT. BMD declined by 1.7%-4.1% with the greatest change at the hips. Adjusted for change in lean and fat body mass, DXA changes remained significant for total body and hip. Serum carboxy-terminal collagen crosslinks telopeptide and alkaline phosphatase increased at 12 months post-TPIAT, suggesting possible increased bone remodeling. BMD, BMD Z-score, and BMC did not change between 12 months and 18 months in any of the four regions (p > 0.6).<h4>Conclusions</h4>TPIAT is associated with decreases in BMD in the body, lumbar, and hip regions of patients with CP in the first year after TPIAT but these appear to stabilize between 12 and 18 months after TPIAT."],"journal":["Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]"],"pubmed_title":["Reduced bone mineral density in the first year after total pancreatectomy with islet autotransplantation (TPIAT)."],"pmcid":["PMC8629939"],"funding_grant_id":["UL1 TR002494","UL1TR002494","K23 DK084315","R01 DK109124"],"pubmed_authors":["McEachron KR","Harindhanavudhi T","Kirchner V","Freeman ML","Pruett TL","Trikudanathan G","Aidoo R","Hodges JS","Beilman GJ","Wothe JK","Bellin MD"],"additional_accession":[]},"is_claimable":false,"name":"Reduced bone mineral density in the first year after total pancreatectomy with islet autotransplantation (TPIAT).","description":"<h4>Background/objectives</h4>The effect of total pancreatectomy with islet autotransplantation (TPIAT) on bone mineral density (BMD) in patients with CP is unknown. We aimed to assess bone health in patients with CP after TPIAT.<h4>Methods</h4>We measured BMD, BMD Z-score, and bone mineral content (BMC) for total body, lumbar spine, right and left hip in 78 patients before and after TPIAT using dual-energy X-ray absorptiometry (DXA, n = 78 pre-TPIAT, n = 65 paired pre- and 12 months post-TPIAT, n = 33 paired 12 and 18 months post-TPIAT), and tested for association with clinical history including age, smoking status, and medications using paired and two-sample t-tests, linear regression, and Fisher's exact test. Laboratory measures related to bone health were also assessed.<h4>Results</h4>In the patients with pre-TPIAT DXA, 12% had low BMD (Z-score ≤ -2). BMD, BMD Z-score, and BMC all decreased from pre-to 12 months post-TPIAT. BMD declined by 1.7%-4.1% with the greatest change at the hips. Adjusted for change in lean and fat body mass, DXA changes remained significant for total body and hip. Serum carboxy-terminal collagen crosslinks telopeptide and alkaline phosphatase increased at 12 months post-TPIAT, suggesting possible increased bone remodeling. BMD, BMD Z-score, and BMC did not change between 12 months and 18 months in any of the four regions (p > 0.6).<h4>Conclusions</h4>TPIAT is associated with decreases in BMD in the body, lumbar, and hip regions of patients with CP in the first year after TPIAT but these appear to stabilize between 12 and 18 months after TPIAT.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2024-11-09T02:10:20.578Z","creation":"2024-11-09T02:10:20.578Z"},"accession":"S-EPMC8629939","cross_references":{"pubmed":["34538580"],"doi":["10.1016/j.pan.2021.08.013"]}}