{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(46)"],"submitter":["Wang Q"],"pubmed_abstract":["A novel CuBr-catalyzed hydroxytrifluoromethylation reaction was investigated. Substituted 3-benzylidene-2-arylisoindolin-1-ones was reacted with sodium trifluoromethanesulfinate to afford substituted-3-hydroxy-2-aryl-3-(2,2,2-trifluoro-1-arylethyl)isoindolin-1-one. The reaction proceeded at 25 °C in air atmosphere in the absence of base and ligands. Our results indicate that trifluoromethyl free radical tends to attack a double bond rather than aryl in this reaction."],"journal":["RSC advances"],"pagination":["25961-25965"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9082868"],"repository":["biostudies-literature"],"pubmed_title":["Copper(i) reagent-promoted hydroxytrifluoromethylation of enamides: flexible synthesis of substituted-3-hydroxy-2-aryl-3-(2,2,2-trifluoro-1-arylethyl)isoindolin-1-one."],"pmcid":["PMC9082868"],"pubmed_authors":["Zeng R","Wang Q","Shi P"],"additional_accession":[]},"is_claimable":false,"name":"Copper(i) reagent-promoted hydroxytrifluoromethylation of enamides: flexible synthesis of substituted-3-hydroxy-2-aryl-3-(2,2,2-trifluoro-1-arylethyl)isoindolin-1-one.","description":"A novel CuBr-catalyzed hydroxytrifluoromethylation reaction was investigated. Substituted 3-benzylidene-2-arylisoindolin-1-ones was reacted with sodium trifluoromethanesulfinate to afford substituted-3-hydroxy-2-aryl-3-(2,2,2-trifluoro-1-arylethyl)isoindolin-1-one. The reaction proceeded at 25 °C in air atmosphere in the absence of base and ligands. Our results indicate that trifluoromethyl free radical tends to attack a double bond rather than aryl in this reaction.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jul","modification":"2024-11-20T10:19:28.27Z","creation":"2024-11-20T10:19:28.27Z"},"accession":"S-EPMC9082868","cross_references":{"pubmed":["35541984"],"doi":["10.1039/c8ra04088e"]}}