{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kondur HR"],"funding":["National Institute of Allergy and Infectious Diseases","NIDA NIH HHS","NIAID NIH HHS","NIMH NIH HHS","National Institute on Drug Abuse"],"pagination":["446-455"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9474700"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(3)"],"pubmed_abstract":["Although co-occurring methamphetamine (meth) use and HIV amplify the risk for neuropsychiatric comorbidities, the underlying neuroimmune mechanisms are not well characterized. We examined whether a detectable viral load and dysregulated metabolism of amino acid precursors for neurotransmitters predicted subsequent levels of sexual compulsivity and sexual sensation seeking. This 15-month longitudinal study enrolled 110 sexual minority men (SMM) living with HIV who had biologically confirmed meth use (i.e., reactive urine or hair toxicology results). Peripheral venous blood samples collected at baseline, 6 months, 12 months, and 15 months were used to measure a detectable viral load (> 40 copies/mL), the kynurenine/tryptophan (K/T) ratio, and the phenylalanine/tyrosine (P/T) ratio. The K/T and P/T ratios index dysregulated serotonin and catecholamine (e.g., dopamine) synthesis, respectively. In a cross-lagged panel model, a detectable viral load at 6 months predicted greater sexual compulsivity at 12 months after adjusting for prior levels of sexual compulsivity and recent stimulant use (β = 0.26, p = 0.046). A greater P/T ratio at baseline predicted decreased sexual sensation seeking at 6 months (β = - 0.25, p = 0.004) after adjusting for baseline sexual sensation seeking and recent stimulant use. Taken together, HIV replication and dysregulated catecholamine synthesis could potentiate sexual compulsivity while decreasing sexual pleasure in SMM who use meth."],"journal":["Journal of neurovirology"],"pubmed_title":["HIV-related drivers of sexual compulsivity and sexuality in sexual minority men who use methamphetamine."],"pmcid":["PMC9474700"],"funding_grant_id":["P30-AI027763","P30 AI073961","P30 AI027763","K24 MH093225","R01 DA033854","P30-AI073961","R01-DA033854"],"pubmed_authors":["Dilworth SE","Kondur HR","Lee TK","Gomez W","Grov C","McIntosh R","Neilands TB","Carrico AW","Paul R","Fuchs D","Gouse H"],"additional_accession":[]},"is_claimable":false,"name":"HIV-related drivers of sexual compulsivity and sexuality in sexual minority men who use methamphetamine.","description":"Although co-occurring methamphetamine (meth) use and HIV amplify the risk for neuropsychiatric comorbidities, the underlying neuroimmune mechanisms are not well characterized. We examined whether a detectable viral load and dysregulated metabolism of amino acid precursors for neurotransmitters predicted subsequent levels of sexual compulsivity and sexual sensation seeking. This 15-month longitudinal study enrolled 110 sexual minority men (SMM) living with HIV who had biologically confirmed meth use (i.e., reactive urine or hair toxicology results). Peripheral venous blood samples collected at baseline, 6 months, 12 months, and 15 months were used to measure a detectable viral load (> 40 copies/mL), the kynurenine/tryptophan (K/T) ratio, and the phenylalanine/tyrosine (P/T) ratio. The K/T and P/T ratios index dysregulated serotonin and catecholamine (e.g., dopamine) synthesis, respectively. In a cross-lagged panel model, a detectable viral load at 6 months predicted greater sexual compulsivity at 12 months after adjusting for prior levels of sexual compulsivity and recent stimulant use (β = 0.26, p = 0.046). A greater P/T ratio at baseline predicted decreased sexual sensation seeking at 6 months (β = - 0.25, p = 0.004) after adjusting for baseline sexual sensation seeking and recent stimulant use. Taken together, HIV replication and dysregulated catecholamine synthesis could potentiate sexual compulsivity while decreasing sexual pleasure in SMM who use meth.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2024-11-05T20:22:46.324Z","creation":"2024-11-05T20:22:46.324Z"},"accession":"S-EPMC9474700","cross_references":{"pubmed":["35821194"],"doi":["10.1007/s13365-022-01085-0"]}}