Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-11166

ABSTRACT: Local regulation and clinical impact of complement gene expression in deceased and living donor kidney allografts

PROVIDER: E-GEOD-11166 | ExpressionAtlas | 2025-01-16

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-11166-analysis-methods.tsv	Tabular
	E-GEOD-11166-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-11166-configuration.xml	Xml
	E-GEOD-11166-percentile-ranks.tsv	Tabular
	E-GEOD-11166.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 107

Similar Datasets

Homo sapiens

Project description:Local regulation and clinical impact of complement gene expression in deceased and living donor kidney allografts

| PRJNA106859 | ENA

E-GEOD-22866

Project description:DNA Methylation Profiling of Glioblastoma: Impact on Gene Expression and Clinical Outcome (Agilent Expression Study)

2025-01-24 | E-GEOD-22866 | ExpressionAtlas

Local regulation and clinical impact of complement gene expression in deceased and living donor kidney allografts

Project description:The biopsy samples obtained at implantation segregated in 2 distinct groups according to donor origin, with a cluster of 319 unique identified genes higher expressed in DD compared to LD kidneys, and 329 genes lower expressed (false discovery rate <5%). Using pathway analysis software a significant local renal overrepresentation of complement genes in DD implantation biopsies was identified. Complement gene expression in DD kidneys related both to donor death and cold ischemia duration, and was associated with a slower onset of renal allograft function. In post-transplantation protocol biopsies, there was a continued overexpression of complement genes, regardless of donor source. The local renal complement gene expression variability in post-transplantation biopsies correlated with renal graft function. This study demonstrates a significant and clinically relevant local overexpression of complement genes in DD kidneys at engraftment and continuous functionally important regulation of complement gene expression after transplantation, regardless of donor source. Targeted therapy interfering with complement activation is an attractive therapeutic target that deserves further investigation in solid organ transplantation. Keywords: time course, genomics gene expression

2008-04-16 | GSE11166 | GEO

E-GEOD-48944

Project description:Gene expression profiles of Chronic kidney disease

2025-01-24 | E-GEOD-48944 | ExpressionAtlas

Local regulation and clinical impact of complement gene expression in deceased and living donor kidney allografts

2008-04-16 | E-GEOD-11166 | biostudies-arrayexpress

E-GEOD-66494

Project description:Development of gene expression profiles in human chronic kidney disease

2025-01-24 | E-GEOD-66494 | ExpressionAtlas

E-GEOD-20636

Project description:Gene expression in OVE26 diabetic kidney during the development of nephropathy

2015-09-15 | E-GEOD-20636 | ExpressionAtlas