Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA105863
PROVIDER: E-GEOD-11981 | ExpressionAtlas | 2020-07-28
REPOSITORIES: ExpressionAtlas
Action | DRS | |||
---|---|---|---|---|
E-GEOD-11981-analysis-methods.tsv | Tabular | |||
E-GEOD-11981-atlasExperimentSummary.Rdata | Rdata | |||
E-GEOD-11981-configuration.xml | Xml | |||
E-GEOD-11981-percentile-ranks.tsv | Tabular | |||
E-GEOD-11981.condensed-sdrf.tsv | Tabular |
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Nature 20080827 7211
Ligand-dependent activation of the hedgehog (Hh) signalling pathway has been associated with tumorigenesis in a number of human tissues. Here we show that, although previous reports have described a cell-autonomous role for Hh signalling in these tumours, Hh ligands fail to activate signalling in tumour epithelial cells. In contrast, our data support ligand-dependent activation of the Hh pathway in the stromal microenvironment. Specific inhibition of Hh signalling using small molecule inhibitors ...[more]