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E-GEOD-23909

ABSTRACT: Transcription profiling by array of HUVEC cells after treatment with valproic acid

OTHER RELATED OMICS DATASETS IN: PRJNA130543

PROVIDER: E-GEOD-23909 | ExpressionAtlas | 2014-07-03

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-23909-analysis-methods.tsv	Tabular
	E-GEOD-23909-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-23909-configuration.xml	Xml
	E-GEOD-23909-percentile-ranks.tsv	Tabular
	E-GEOD-23909-zoomifications-log.tsv	Tabular

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1 - 5 of 65

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Transcription profiling by array of human umbilical vein endothelial cells treated with valproic acid

Project description:Valproic acid (VPA) is a short-chain fatty acid used in the treatment of epilepsy and also considered to be an epigenetic modifier by functioning as a histone deacetylase (HDAC)-inhibitor. The aim of this study was to search for gene altered by VPA in human endothelial cells. Human umbilical vein endothelial cells (HUVEC) from five individuals were cultured in the absence or presence of 4mM VPA for 24h. Cells were cultured in EGM-2 medium and all experiments were performed in passages 1 or 2.

2012-03-14 | E-GEOD-23909 | biostudies-arrayexpress

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human placenta-derived cell line (JEG-3): Control vs. valproic acid(VPA)-treated

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Project description:Valproic acid (VA) is a small-chain branched fatty acid, widely used as anticonvulsant, and mood stabilizer to treat psychiatric illness. Valproic acid is also known to inhibit the histone deacetylases (HDACs), which makes it as a potent antitumor agent in alone or in combination with other cytotoxic drugs. Beside its conventional activities, valproic acid reported to have much broader, complicated effects and affect many complex physiological processes. However the molecular mechanisms of valproic acid are unclear. So, we used budding yeast transcriptome analysis to better understand the molecular mechanism of action of valproic acid. The clusters of differentially expressed genes in microarray after VA (6mM) treatment and their functional enrichment analysis revealed its overall effects on various biological processes such as cell cycle, signal transduction, metabolism, transcription, ubiquitination, transporter activities and many more. The microarray data were validated by quantitative real-time PCR.

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human placenta-derived cell line (JEG-3): Control vs. valproic acid(VPA)-treated

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