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E-GEOD-30979

ABSTRACT: Gene expression in hypoxic non-small cell lung cancer

OTHER RELATED OMICS DATASETS IN: PRJNA146187

PROVIDER: E-GEOD-30979 | ExpressionAtlas | 2015-08-17

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-30979-analysis-methods.tsv	Tabular
	E-GEOD-30979-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-30979-configuration.xml	Xml
	E-GEOD-30979-percentile-ranks.tsv	Tabular
	E-GEOD-30979.condensed-sdrf.tsv	Tabular

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Project description:Gene expression in hypoxic non-small cell lung cancer

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Project description:Hypoxia triggers aggressive cancer growth and contributes to chemotherapy resistance. Novel therapeutic strategies aim at targeting hypoxia activated signaling pathways. Tumor hypoxia not only affects neoplastic tumor cells but also the surrounding stroma cells. Therefore, a novel ex vivo model was established, which allows the study of hypoxia effects in fragments of non-small cell lung cancer (NSCLC) with preserved tumor microenvironment and 3D-structure. Microarray analysis identified 107 significantly regulated genes with at least two-fold expression change in hypoxic compared to normoxic fragments. However, only four genes were significantly regulated in both subtypes, adenocarcinoma and squamous cell carcinoma. The hypoxic regulation of these four genes was verified in an independent set using quantitative PCR. Non-small cell lung cancer (NSCLC) fragments were cultured ex vivo under hypoxia or normoxia for three days. cDNA microarray analysis was performed in hypoxic and normoxic lung cancer fragments from ten patients.

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