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E-GEOD-31986

ABSTRACT: Pemetrexed alters inflammatory profile in EA.hy 926 cells grown under low-folate conditions.

OTHER RELATED OMICS DATASETS IN: PRJNA145173

PROVIDER: E-GEOD-31986 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-31986-analysis-methods.tsv	Tabular
	E-GEOD-31986-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-31986-configuration.xml	Xml
	E-GEOD-31986-percentile-ranks.tsv	Tabular
	E-GEOD-31986.condensed-sdrf.tsv	Tabular

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Homo sapiens

Project description:Pemetrexed alters inflammatory profile in EA.hy 926 cells grown under low-folate conditions.

| PRJNA145173 | ENA

Pemetrexed alters inflammatory profile in EA.hy 926 cells grown under low-folate conditions.

2012-10-03 | GSE31986 | GEO

Methotrexate activates aspects of inflammation in EA.hy 926 cells

Project description:Methotrexate (MTX) is an anti-folate drug used to treat inflammatory diseases such as rheumatoid arthritis. The changes induced by MTX were profiled within EA.hy 926 cells grown in normal (Hi) and low (Lo) folate. Several inflammatory genes were up regulated and several mitosis related genes were down regulated.

2012-09-30 | GSE32008 | GEO

Methotrexate activates aspects of inflammation in EA.hy 926 cells

2012-09-30 | E-GEOD-32008 | biostudies-arrayexpress

Pemetrexed alters inflammatory profile in EA.hy 926 cells grown under low-folate conditions.

Project description:Pemetrexed is an antifolate drug used in the treatment of lung cancer. EA.hy 926 cells grown under low (Lo) and normal (Hi) folate conditions were treated with PMX. Microarray analysis was used to examine changes in gene expression due to PMX treatment. Hi and Lo cells were grown to confluence and maintained in fresh medium for 24 hours prior to treatment with 0.5uM PMX for 48 hours.

2012-10-03 | E-GEOD-31986 | biostudies-arrayexpress

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