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E-GEOD-33443

ABSTRACT: Microarray analysis of gene expression profiles in response to tomato leaves extract treatment in MCF-7 breast cancer cells

OTHER RELATED OMICS DATASETS IN: PRJNA148699

PROVIDER: E-GEOD-33443 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-33443-analysis-methods.tsv	Tabular
	E-GEOD-33443-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-33443-configuration.xml	Xml
	E-GEOD-33443-configuration.xml.beforeQC	Xml
	E-GEOD-33443-percentile-ranks.tsv	Tabular

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Project description:Microarray analysis of gene expression profiles in response to tomato leaves extract treatment in MCF-7 breast cancer cells

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Microarray analysis of gene expression profiles in response to tomato leaves extract treatment in MCF-7 breast cancer cells

2011-11-05 | GSE33443 | GEO

Microarray analysis of gene expression profiles in response to tomato leaves extract treatment in MCF-7 breast cancer cells

Project description:Microarray analysis was performed to evaluate the global gene expression profiles of MCF-7 breast cancer cells treated with tomato leaves extract (TLE) in 1 hr and 48 hrs of treatment. Several of genes with p < 0.05 and fold-change cut-off <2.00 from human genome had significantly changed after the treatments. Its showed the greatest roles in cancer cells growth and were found either to be down-regulated or up-regulated in cells after the treatment.TLE gave significant expression effects towards several genes such as CRYAB, PIM1, BTG1, CYR61, HIF1A, CEBP-beta, TXNIP, THBS1, HMG1L1 and HIST2H3D genes. These results demonstrate the potent activity of TLE as an anti-cancer agent. We analyzed untreated (0 hr) and treated MCF-7 breast cancer cells (after 1 hr and 48hrs) using the Affymetrix Human Exon 1.0 ST platform. Chip array was scanned by Affymetrix Microarray Suite/GCOS. Experiment were performed in triplicates. Raw data was processed by GeneSpringGX v7.2 (Agilent Technology, USA).

2011-11-05 | E-GEOD-33443 | biostudies-arrayexpress

Expression data from MCF-7 breast cancer cells treated with Wild Type Tomato fruit extract (WT) and transgenic lines tomato fruit extract (L6 and L7)

Project description:To investigate the effects of transgenic lines L6 and L7 tomato fruits on total expression profile of MCF-7 breast cancer cells, we treated MCF-7 cells with 1 ug/ml of tomato fruit extract for 24 hours and compare it with wild type tomato fruit extract Objectives for this study included the identification of genes that were up or down-regulated at the transcriptional level in MCF-7 cells treated with transgenic lines L6 and L7 tomatofruit extract and compare it to wild type tomato fruit extract.

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