Project description:To investigate the effects of transgenic lines L6 and L7 tomato fruits on total expression profile of MCF-7 breast cancer cells, we treated MCF-7 cells with 1 ug/ml of tomato fruit extract for 24 hours and compare it with wild type tomato fruit extract Objectives for this study included the identification of genes that were up or down-regulated at the transcriptional level in MCF-7 cells treated with transgenic lines L6 and L7 tomatofruit extract and compare it to wild type tomato fruit extract.

2017-06-12 | GSE94548 | GEO

Microarray analysis of gene expression profiles in response to tomato leaves extract treatment in MCF-7 breast cancer cells

Project description:Microarray analysis was performed to evaluate the global gene expression profiles of MCF-7 breast cancer cells treated with tomato leaves extract (TLE) in 1 hr and 48 hrs of treatment. Several of genes with p < 0.05 and fold-change cut-off <2.00 from human genome had significantly changed after the treatments. Its showed the greatest roles in cancer cells growth and were found either to be down-regulated or up-regulated in cells after the treatment.TLE gave significant expression effects towards several genes such as CRYAB, PIM1, BTG1, CYR61, HIF1A, CEBP-beta, TXNIP, THBS1, HMG1L1 and HIST2H3D genes. These results demonstrate the potent activity of TLE as an anti-cancer agent. We analyzed untreated (0 hr) and treated MCF-7 breast cancer cells (after 1 hr and 48hrs) using the Affymetrix Human Exon 1.0 ST platform. Chip array was scanned by Affymetrix Microarray Suite/GCOS. Experiment were performed in triplicates. Raw data was processed by GeneSpringGX v7.2 (Agilent Technology, USA).

2011-11-05 | E-GEOD-33443 | biostudies-arrayexpress

E-GEOD-59251

Project description:RNA-sequencing experiment: Treatment of MCF-7 breast cancer cells with the novel small molecule ZNA

2025-01-24 | E-GEOD-59251 | ExpressionAtlas

E-GEOD-18912

Project description:Expression profiling of breast cancer cell lines MCF-7 and MCF-7R4

2025-01-24 | E-GEOD-18912 | ExpressionAtlas

E-GEOD-21947

Project description:Gene expression profiles of breast cancer subtypes are detectable in histologically normal breast epithelium

2025-01-24 | E-GEOD-21947 | ExpressionAtlas

E-GEOD-11791

Project description:Transcription profiling by array of human MCF-7 breast cancer cells

2025-01-16 | E-GEOD-11791 | ExpressionAtlas

Modulation of apple leaf trancriptome by tomato cutin monomer extract

Project description:Investigation of whole genome gene expression level changes in leaves of apple seedlings (Golden delicious) 3 days after treatment by tomato cutin monomer extract (CME) versus formulation blank (FB). CME is a formulated extract enriched of hydroxy fatty acids from tomato cuticle

2024-02-09 | GSE245564 | GEO

E-GEOD-42024

Project description:Characterization of gene expression profiles induced by HIC-1 reactivation on breast cancer

2025-01-24 | E-GEOD-42024 | ExpressionAtlas