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E-GEOD-34961

ABSTRACT: Expression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML

OTHER RELATED OMICS DATASETS IN: PRJNA156135PRJNA156137PRJNA156139PRJNA150949

PROVIDER: E-GEOD-34961 | ExpressionAtlas | 2015-09-22

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-34961-analysis-methods.tsv	Tabular
	E-GEOD-34961-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-34961-configuration.xml	Xml
	E-GEOD-34961-configuration.xml.beforeQC	Xml
	E-GEOD-34961-percentile-ranks.tsv	Tabular

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Project description:This SuperSeries is composed of the following subset Series: GSE34959: Expression profiling of primary wild type (WT), Ezh2-null and Eed-null murine MLL-AF9 AML GSE34961: Expression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML GSE34962: Epigenetic profiling of WT and Ezh2-null MLL-AF9 murine leukemic cells Refer to individual Series

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Expression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML

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Project description:We used EZH2i-targeted hematological malignancies as an examples and focused on molecular characterization of EZH2 Y641 mutant hematological cell lines. We used the proteomic strategies and compared the protein expression level and lysine methylation level (including mono-, di-, and trimethylaiton) in EZH2 wild-type (EZH2 WT), EZH2 Y641N and Y641F (EZH2 MUT) cell lines.

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Expression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML

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