E-GEOD-39351
Ontology highlight
ABSTRACT:
PROVIDER: E-GEOD-39351 | ExpressionAtlas | 2015-07-08
REPOSITORIES: ExpressionAtlas
Similar Datasets
Project description:Expression data from murine intestinal tissue upon depletion of regulatory T cells
| PRJNA170685 | ENA
Project description:Expression data from murine liver tissue upon depletion of regulatory T cells
| PRJNA153009 | ENA
Project description:Regulatory T cells (Treg) play a pivotal role in modulating immune responses and were shown to decrease atherosclerosis in murine models. How this effect is brought about remains elusive. We used microarrays to detail the global programme of gene expression in intestinal tissue from chimeric DEREG x Ldlr-/- mice +/- diphteria toxin enabling selective depletion of Treg. Chimeric DEREG x Ldlr-/- mice were kept on a high fat diet for 8 weeks and treated with DT or PBS i.p. for 8 weeks. Upon harvest, intestinal tissue was ascertained from animals from both groups and a gene array was performed.
2013-07-10 | E-GEOD-39351 | biostudies-arrayexpress
Project description:Regulatory T cells (Treg) play a pivotal role in modulating immune responses and were shown to decrease atherosclerosis in murine models. How this effect is brought about remains elusive. We used microarrays to detail the global programme of gene expression in intestinal tissue from chimeric DEREG x Ldlr-/- mice +/- diphteria toxin enabling selective depletion of Treg.
2013-07-10 | GSE39351 | GEO
Project description:Regulatory T cells (Treg) play a pivotal role in modulating immune responses and were shown to decrease atherosclerosis in murine models. How this effect is brought about remains elusive. We used microarrays to detail the global programme of gene expression in liver tissue from chimeric DEREG x Ldlr-/- mice +/- diphteria toxin enabling selective depletion of Treg. Chimeric DEREG x Ldlr-/- mice were kept on a high fat diet for 8 weeks and treated with DT (vehicle) or PBS (placebo) i.p. for 8 weeks. Upon harvest, liver tissue was ascertained from animals from both groups and a gene array was performed.
2012-12-31 | E-GEOD-36279 | biostudies-arrayexpress
Project description:Expression data from laser microdissected murine intestinal epithelial cells
| PRJNA189969 | ENA
Project description:Studies over the past decade characterized murine regulatory T cells (Tregs) with the capacity to promote tissue regeneration. In humans, such a population of tissue-repair Treg cells has not been discovered yet. Using single-cell chromatin accessibility profiles of murine and human tissue Treg cells, we defined a species-conserved and microbiota-independent repair Treg signature, with a prevailing footprint of the transcription factor BATF. Combining this signature with gene expression profiling and TCR fate mapping, we identified a population of tissue-like Treg cells in peripheral blood, characterized by the expression of BATF, CCR8 and HLA-DR. Human BATF+CCR8+ Treg cells from normal skin and adipose tissue shared features with tumor-resident Treg and tissue T-follicular helper (Tfh) cells. Inducing a Tfh-like differentiation program in naive Treg cells partially recapitulated human tissue Treg characteristics, including enhanced wound healing potential
| EGAS00001004900 | EGA
Project description:Several studies over the past decade identified a subpopulation of murine regulatory T cells (Tregs) which have the intrinsic capacity to promote tissue homeostasis and, upon damage, enhance tissue regeneration and re-organization. In humans, this population of tissue regeneration-promoting Treg cells has not been identified and characterized yet. Using single-cell chromatin accessibility as well as single-cell RNA and TCR expression profiles of murine and human tissue-derived CD4 T cells, we identified the murine Treg repair signature and performed a liftover on human single T cell data. We identified a FOXP3+CCR8+HLA-DR+ population in peripheral blood, which has characteristics of human tissue Treg cells and promotes tissue regeneration and wound healing in-vitro. This population was dependent on the transcriptional regulator BATF, a factor that also drives the development of tissue regeneration-promoting Treg cells in the murine system. Human CCR8+HLA-DR+ Treg cells could be used as a novel T-cell product to promote tissue repair in regenerative medicine.
2021-03-25 | GSE156112 | GEO