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E-GEOD-51386

ABSTRACT: SARS infection of C57BL6, TIMP1 and Serpine1 knock-out mice

PROVIDER: E-GEOD-51386 | ExpressionAtlas | 2020-05-06

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-GEOD-51386-analysis-methods.tsv	Tabular
	E-GEOD-51386-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-51386-configuration.xml	Xml
	E-GEOD-51386-percentile-ranks.tsv	Tabular
	E-GEOD-51386.condensed-sdrf.tsv	Tabular

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Project description:This purpose of this experiment was to investigate the transcriptional differences between C57BL6, PLAT knock-out mice infected with SARS MA15 virus. Overview of Experiment: Groups of 20 week old C57BL6 and PLAT knock-out mice were infected with SARS MA15 virus. Infections were done at 10^5 PFU or time-matched mock infected. Time points were 4 and 7 d.p.i. There were 2-4 animals/dose/time point. Lung samples were collected for virus load, transcriptional and proteomics analysis. Weight loss and animal survival were also monitored.

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Project description:This purpose of this experiment was to investigate the transcriptional differences between C57BL6, TIMP1 and Serpine1 knock-out mice infected with SARS MA15 virus. Overview of Experiment: Groups of 20 week old C57BL6, TIMP1 and Serpine1 (PAI1) knock-out mice were infected with SARS MA15 virus. Infections were done at 10^4 PFU or time-matched mock infected. Time points were 4 and 7 d.p.i. There were 2-4 animals/dose/time point. Lung samples were collected for virus load, transcriptional and proteomics analysis. Weight loss and animal survival were also monitored.

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