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E-GEOD-55098

ABSTRACT: Expression data from peripheral blood mononuclear cell in patients with type 1 diabetes compared with normal controls

DISEASE(S): Normal,Type I Diabetes Mellitus

PROVIDER: E-GEOD-55098 | ExpressionAtlas | 2014-09-02

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-55098-analysis-methods.tsv	Tabular
	E-GEOD-55098-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-55098-configuration.xml	Xml
	E-GEOD-55098-percentile-ranks.tsv	Tabular
	E-GEOD-55098.condensed-sdrf.tsv	Tabular

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Expression data from peripheral blood mononuclear cell in patients with type 1 diabetes compared with normal controls

Project description:Type 1 diabetes mellitus (T1D) is a common autoimmune disease mediated by autoimmune attack against pancreatic b cells.Dys-regualtion of the component of peripheral blood mononuclear cells (PBMCs), including T-cells and B-cells, and smaller amounts of NK cells and dendritic cells, have all been implicated in this process This study sought to identify T1D associated differently expressed genes in the peripheral blood mononuclear cell (PBMC). Peripheral blood mononuclear of newly diagnosed type1 diabetes patients and normal controls were purified by LymphoprepTm gradient purification according to the manufacturer’s instructions (Axis-Shield PoC AS, Oslo, Norway) for futher microarray analysis.

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Project description:Type 1 diabetes mellitus (T1D) is a common autoimmune disease mediated by autoimmune attack against pancreatic b cells. It has been reported that dys-regulation of microRNAs (miRNAs) may contribute to the pathogenesis of autoimmune diseases, including T1D. This study sought to identify T1D associated miRNAs in the peripheral blood mononuclear cell (PBMC). Peripheral blood mononuclear of newly diagnosed type1 diabetes patients and normal controls were purified by LymphoprepTm gradient purification according to the manufacturerM-bM-^@M-^Ys instructions (Axis-Shield PoC AS, Oslo, Norway) for futher microarray analysis.

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