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E-GEOD-58078

ABSTRACT: Microarray analysis of WT and Tfap4-KO CD8 T cells during early activation

OTHER RELATED OMICS DATASETS IN: PRJNA248823PRJNA248821PRJNA248826PRJNA248824PRJNA248825PRJNA248822

PROVIDER: E-GEOD-58078 | ExpressionAtlas | 2015-07-29

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-GEOD-58078-analysis-methods.tsv	Tabular
	E-GEOD-58078-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-58078-configuration.xml	Xml
	E-GEOD-58078-percentile-ranks.tsv	Tabular
	E-GEOD-58078.condensed-sdrf.tsv	Tabular

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Microarray analysis of WT and Tfap4-KO CD8 T cells during early activation

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Genome-wide mapping of Myc, AP4, and phosphorylated RNA polymerase II binding in activated CD8 T cells by ChIP sequencing

Project description:The trasncription factor cMyc is an essential transcription factor that establishes a metabolically active and proliferative state in T cells after antigen priming. However, its expression is transient. To date, it remains unknown how T cell activation is maintained after cMyc down-regulation. Here, we identify AP4, encoded by the gene Tfap4, as the transcription factor that is induced by cMyc and sustains activation of antigen-specific CD8+ T cells. Despite normal priming, Tfap4–/– CD8+ T cells fail to continue transcription of a broad range of cMyc gene targets necessary for sustained proliferation. Genome-wide analysis suggests that many activation-induced metabolic genes are shared targets of cMyc and AP4. Thus, AP4 maintains Myc-initiated cellular activation programs in CD8+ T cells to control microbial infections. Naive CD8+ T cells from C57BL6 mice were activated with anti-CD3 and anti-CD28 stimulation in vitro for two days and genome-wide occupancy of Myc, AP4 and Ser2 or Ser5 phipsphorylated RNA polymerase II was profiled by chromatin immunoprecipitation and high-throughput sequencing.

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