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E-GEOD-58085

ABSTRACT: Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [8_week_ileal]

PROVIDER: E-GEOD-58085 | ExpressionAtlas | 2014-09-08

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-58085-analysis-methods.tsv	Tabular
	E-GEOD-58085-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-58085-configuration.xml	Xml
	E-GEOD-58085-percentile-ranks.tsv	Tabular
	E-GEOD-58085.condensed-sdrf.tsv	Tabular

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E-GEOD-58086

Project description:Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [30_week_Liver]

2014-09-08 | E-GEOD-58086 | ExpressionAtlas

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Project description:Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [8_week_ileal]

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Project description:Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [RNA-Seq]

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Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences

Project description:This SuperSeries is composed of the SubSeries listed below. Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. Refer to individual Series

2014-09-01 | E-GEOD-58087 | biostudies-arrayexpress

E-GEOD-30485

Project description:Gene expression accompanying the promotion of hepatocellular carcinoma by intestinal microbiota and Tlr4 in mice.

2014-10-10 | E-GEOD-30485 | ExpressionAtlas

Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [8_week_ileal]

Project description:Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. Male mice were exposed to low-dose penicillin (6.7 mg/L), from birth. Ileums were collected at 8 weeks of age, RNA was extracted, and transcriptional differences were measured by microarray analysis.

2014-09-01 | E-GEOD-58085 | biostudies-arrayexpress

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Project description:Interplay of host microbiota, genetic perturbations, and inflammation promote local development of intestinal neoplasms in mice

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