Mouse gut metagenome
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA248660 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [30_week_Liver]
2014-09-08 | E-GEOD-58086 | ExpressionAtlas
Project description:Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [8_week_ileal]
2014-09-08 | E-GEOD-58085 | ExpressionAtlas
Project description:Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [8_week_ileal]
| PRJNA248916 | ENA
Project description:Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [30_week_Liver]
| PRJNA248917 | ENA
Project description:Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [RNA-Seq]
| PRJNA248883 | ENA
Project description:To characterize the effect of microbiota on global gene expression in the distal small intestine during postnatal gut development we employed mouse models with experimental colonization by intestinal microbiota. Using microarray analysis to assess global gene expression in ileal mucosa at the critical stage of intestinal development /maturation associated with weaning, and asking how expression is affected by microbial colonization In the study presented here, preweaned and postweaned GF, SPF mouse small intestinal total RNAs were used. Also, 3-week-old gnotobiotic mouse as well as GF mouse small intestinal RNAs were used.
2013-03-02 | E-GEOD-44788 | biostudies-arrayexpress
Project description:To characterize the effect of microbiota on global gene expression in the distal small intestine during postnatal gut development we employed mouse models with experimental colonization by intestinal microbiota. Using microarray analysis to assess global gene expression in ileal mucosa at the critical stage of intestinal development /maturation associated with weaning, and asking how expression is affected by microbial colonization
2013-03-02 | GSE44788 | GEO
Project description:Gut microbiome research is rapidly moving towards the functional characterization of the microbiota by means of shotgun meta-omics. Here, we selected a cohort of healthy subjects from an indigenous and monitored Sardinian population to analyze their gut microbiota using both shotgun metagenomics and shotgun metaproteomics. We found a considerable divergence between genetic potential and functional activity of the human healthy gut microbiota, in spite of a quite comparable taxonomic structure revealed by the two approaches. Investigation of inter-individual variability of taxonomic features revealed Bacteroides and Akkermansia as remarkably conserved and variable in abundance within the population, respectively. Firmicutes-driven butyrogenesis (mainly due to Faecalibacterium spp.) was shown to be the functional activity with the higher expression rate and the lower inter-individual variability in the study cohort, highlighting the key importance of the biosynthesis of this microbial by-product for the gut homeostasis. The taxon-specific contribution to functional activities and metabolic tasks was also examined, giving insights into the peculiar role of several gut microbiota members in carbohydrate metabolism (including polysaccharide degradation, glycan transport, glycolysis and short-chain fatty acid production). In conclusion, our results provide useful indications regarding the main functions actively exerted by the gut microbiota members of a healthy human cohort, and support metaproteomics as a valuable approach to investigate the functional role of the gut microbiota in health and disease.
2017-07-19 | PXD005780 | Pride
Project description:Porphyromonas gingivalis impairs glucose uptake in muscle by altering gut microbiota
| PRJDB9383 | ENA