Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-60502

ABSTRACT: Gene expression profiling of 18 hepatocellular carcinoma and adjacent non-tumorous liver tissue

PROVIDER: E-GEOD-60502 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-60502-analysis-methods.tsv	Tabular
	E-GEOD-60502-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-60502-configuration.xml	Xml
	E-GEOD-60502-percentile-ranks.tsv	Tabular
	E-GEOD-60502.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 39

Similar Datasets

E-GEOD-55092

Project description:Viral Expression and Molecular Profiling in Liver Tissue versus Microdissected Hepatocytes in Hepatitis B Virus - Associated Hepatocellular Carcinoma

2025-01-24 | E-GEOD-55092 | ExpressionAtlas

Homo sapiens

Project description:Gene expression profiling of 18 hepatocellular carcinoma and adjacent non-tumorous liver tissue

| PRJNA258424 | ENA

E-GEOD-49515

Project description:Expression profiling of PBMC from patients with hepatocellular carcinoma

2025-01-24 | E-GEOD-49515 | ExpressionAtlas

Gene expression profiling of 18 hepatocellular carcinoma and adjacent non-tumorous liver tissue

Project description:These paired HCC and non-tumorous liver tissues were used to determine highly differentially expressed genes in HCC and non-tumorous liver tissue. Hepatocellular carcinoma (HCC) is a malignancy with poor survival outcome. Genes showing extreme differential expression between paired human HCC and adjacent non-tumorous liver tissue were investigated. PLVAP was identified as a gene specifically expressed in vascular endothelial cells of HCC but not in non-tumorous liver tissues. This finding was confirmed by RT-PCR analysis of micro-dissected cells and immunohistochemical staining of tissue sections. A recombinant monoclonal anti-PLVAP Fab fragment co-expressing extracellular domain of human tissue factor (TF) was developed. The potential therapeutic effect and toxicity to treat HCC were studied using a Hep3B HCC xenograft model in SCID mice. Infusion of recombinant monoclonal anti-PLVAP Fab-TF into the tumor feeding artery induced tumor vascular thrombosis and extensive tumor necrosis at doses between 2.5 µg and 12 µg. Tumor growth was suppressed for 40 days after a single treatment. Systemic administration did not induce tumor necrosis. Little systemic toxicity was noted for this therapeutic agent. The results of this study suggest that anti-PLVAP Fab-TF may be used to treat HCC cases for which transcatheter arterial chemoembolization (TACE) is currently used, but without major drawbacks of TACE. Anti-PLVAP Fab-TF may improve therapeutic outcome and be a viable therapeutic agent in patients with more advanced disease and compromised liver function. Frozen hepatocellular carcinoma and adjacent non-tumorous liver tissues were used for gnee expression profiling study. Affymetrix U133A genechips were used for gene expression profiling. This dataset is part of the TransQST collection.

2015-01-01 | E-GEOD-60502 | biostudies-arrayexpress

E-GEOD-19665

Project description:Transcription profiling by array of human hepatitis B virus (HBV) and hepatitis C virus (HCV) induced hepatocellular (HCC) carcinoma and surrounding noncancerous liver tissue.

2025-01-24 | E-GEOD-19665 | ExpressionAtlas

Expression profile of Hepatocellular Carcinoma

Project description:Expression profiling of tumor and adjacent non-tumorous tissues of Hepatocellular Carcinoma (HCC) patients. Illumina HumanHT-12 V4.0 expression beadchip was used to obtain expression profiles across more than 31,000 annotated genes. Samples included 59 tumors and 59 adjacent non-tumorous samples.

2014-12-10 | GSE57957 | GEO

Expression profile of Hepatocellular Carcinoma

2014-12-10 | E-GEOD-57957 | biostudies-arrayexpress

Methylation profile of Hepatocellular Carcinoma

2014-12-10 | GSE57956 | GEO

Methylation profile of Hepatocellular Carcinoma

Project description:DNA methylation profiling of tumor and adjacent non-tumorous tissues of Hepatocellular Carcinoma (HCC) patients. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Samples included 59 tumors and 59 adjacent non-tumorous samples. Bisulphite converted DNA from the 59 tumors and 59 adjacent non-tumorous samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip.

2014-12-10 | E-GEOD-57956 | biostudies-arrayexpress

E-GEOD-33006

Project description:Gene expression profiles from the hepatocellular carcinoma (HCC) tissues

2025-01-24 | E-GEOD-33006 | ExpressionAtlas