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Methylation profile of Hepatocellular Carcinoma

ABSTRACT: DNA methylation profiling of tumor and adjacent non-tumorous tissues of Hepatocellular Carcinoma (HCC) patients. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Samples included 59 tumors and 59 adjacent non-tumorous samples. Bisulphite converted DNA from the 59 tumors and 59 adjacent non-tumorous samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip.

ORGANISM(S): Homo sapiens

SUBMITTER: Lee Caroline

PROVIDER: E-GEOD-57956 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Methylation profiles reveal distinct subgroup of hepatocellular carcinoma patients with poor prognosis.

Mah Way-Champ WC Thurnherr Thomas T Chow Pierce K H PK Chung Alexander Y F AY Ooi London L P J LL Toh Han Chong HC Teh Bin Tean BT Saunthararajah Yogen Y Lee Caroline G L CG

PloS one 20140805 8

Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-associated mortality worldwide. However, the role of epigenetic changes such as aberrant DNA methylation in hepatocarcinogenesis remains largely unclear. In this study, we examined the methylation profiles of 59 HCC patients. Using consensus hierarchical clustering with feature selection, we identified three tumor subgroups based on their methylation profiles and correlated these subgroups with clinicopathological parameters. ...[more]

PMID: 25093504

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Hepatocellular Carcinoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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