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E-GEOD-74904

ABSTRACT: Transcription profiling by array of LRAT knockout mice on vitamin A sufficient or deficient diets

PROVIDER: E-GEOD-74904 | ExpressionAtlas | 2016-11-08

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-74904-analysis-methods.tsv	Tabular
	E-GEOD-74904-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-74904-configuration.xml	Xml
	E-GEOD-74904-percentile-ranks.tsv	Tabular
	E-GEOD-74904.condensed-sdrf.tsv	Tabular

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Project description:LRAT knockout mice on vitamin A sufficient or deficient diets were compared to age-matched wild type mice on a vitamin A sufficient diet RNA was isolated from right ventricle of the heart and one array was run for each sample.

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Effects of vitamin A on ventricular myocardium gene expression [left ventricle]

Project description:LRAT knockout mice on vitamin A sufficient or deficient diets were compared to age and gender matched wildtype mice on a vitamin A sufficient diet RNA was isolated from the left ventricle of the heart and one array was run for each sample.

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Effects of vitamin A on Ventricular myocardium gene expression [right ventricle]

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Project description:LRAT knockout mice on vitamin A sufficient or deficient diets were compared to age and gender matched wildtype mice on a vitamin A sufficient diet

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E-GEOD-74905

Project description:Transcription profiling by array of LRAT knockout and wild type mice on vitamin A sufficient or deficient diets

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Project description:This experiment tested the affects of different diets on mice esophagus metabolites. The diets ranged from zinc sufficient to zinc deficient and a third group that included zinc deficient mice that were put back on zinc sufficient diets.

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Metabolomics Workbench ST000331 - GNPS - Effects of Zinc on GI tract metabolites (Part 2: Prostate)

Project description:This experiment tested the affects of different diets on mice prostate metabolites. The diets ranged from zinc sufficient to zinc deficient and a third group that included zinc deficient mice that were put back on zinc sufficient diets.

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Expression data from retinoic acid-sufficient and retinoic acid-deficient mouse airway smooth muscle [mouse ASMs]

Project description:Observational studies in human suggest involvement of vitamin A/retinoic acid (RA) signaling in the regulation of airway smooth muscle (ASM) function, but the precise mechanisms by which RA impacts ASM phenotype is not clear. Here, we generated trascriptional profiles from two different models of RA-sufficient and RA-deficient mouse ASM in order to determine the molecular targets of RA in ASM (VAS/VAD, CTR/BMS) Mouse ASMs were isolated from Acta2-hrGFP;Cspg4-DsRED adult mice using flow cytometry. VAS mice were given normal, vitamin A-sufficient diet (15 IU vitamin/g) while the VAD mice were given 3 days of vitamin A-deficient diet (< 0.1 IU vitamin/g). CTR/BMS mouse ASMs were also isolated from Acta2-hrGFP;Cspg4-DsRED adult mice using flow cytometry. CTR mice were given 3 days of powdered, vitamin A sufficient diet mixed with vehicles (corn oil) while the BMS diet were given 3 days of powdered, vitamin A sufficient diet mixed with a potent pan-RA-receptor antagonist (BMS, 5 mcg/g).

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