Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-2445

ABSTRACT: Transcriptional responses in liver upon acute CCl4 intoxication

PROVIDER: E-MTAB-2445 | ExpressionAtlas | 2015-06-26

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-2445-analysis-methods.tsv	Tabular
	E-MTAB-2445-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-2445-configuration.xml	Xml
	E-MTAB-2445-percentile-ranks.tsv	Tabular
	E-MTAB-2445.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 142

Similar Datasets

Bone morphogenetic protein 8b (bmp8b) in non-alcoholic steatohepatitis (nash), acute hepatic damage and liver regeneration

Project description:TGFβ/BMP family member Bone Morphogenetic Protein 8b (Bmp8b) is upregulated in NASH (Western Diet -WD- Model), acute liver damage (CCl4 model) and by Partial Hepatectomy (PH). Absence of Bmp8b reduces liver inflammation and fibrosis in the NASH model (WD). In the acute (3days) CCl4 model, absence of Bmp8b impacts acute inflammatory responses, hepatic stellate cells (HSC) activation, and compensatory hepatocyte proliferation; defective inflammatory pathways and hepatocytes proliferation is also observed in the Partial hepatectomy model. BMP8b is thus a pathophysiologically relevant target to modulate the responses to damage in acute and chronic liver disease.

2020-04-01 | GSE110404 | GEO

E-MTAB-9250

Project description:Glucocorticoids induced transcriptional regulation in acute lymphoblastic leukemia

2025-01-16 | E-MTAB-9250 | ExpressionAtlas

Transcriptional dynamics of hepatic stellate cells in experimental acute liver injury, liver fibrosis and liver fibrosis reversal.

Project description:Transcriptional alterations during different stages of hepatic stellate cell activation were determined using RNA Sequencing. Models include acute liver injury (1 injection of CCl4) and chronic liver injury (8 injections of CCl4 over 4-week period) with different recovery timepoints. Illumina NextSeq 500 High was used for sequencing.

2021-12-15 | GSE176042 | GEO

E-MTAB-7495

Project description:Transcriptome responses to dexamethasone of the liver of pigs with different genotypes at the GRAla610Val mutation

2019-05-02 | E-MTAB-7495 | ExpressionAtlas

E-MTAB-8865

Project description:Measuring ageing-dependent transcriptional responses to human A42 peptide in Drosophila brain

2020-03-31 | E-MTAB-8865 | ExpressionAtlas

Gene signatures detect damaged LSECs in all chronic liver diseases.

Project description:Transcriptional alterations in LSECs from healthy and damaged livers were determined using RNA Sequencing. Models include acute liver injury (1 ip injection of CCl4) with different timepoints during recovery. Illumina NextSeq 500 High was used for sequencing.

2021-10-08 | GSE180366 | GEO

E-MTAB-2782

Project description:Transcriptional profilling of female mice liver as a function of age

2014-07-23 | E-MTAB-2782 | ExpressionAtlas

Hippo signaling instructs ectopic but not normal organ growth [Liver YapTazKO+CCl4]

Project description:We conditionally deleted Yap/Taz from hepatocytes prior to induction of acute injury by injection of liver toxin carbon tetrachloride (CCl4).

2022-11-19 | GSE211460 | GEO

Rat transcriptomic profiling of liver sinusoidal endothelial cells during chronic liver disease reveals stage-specific secretory signature

Project description:RNAseq was applied to define the transcriptome of primary LSECs from rats with acute liver injury, mild liver fibrosis and advanced chronic liver disease (CLD) (due to CCl4 or thioacetamide administration). Results showed different transcriptomic profile during progression of CLD, and a large number of significant de-regulated genes (1412) were shared in cirrhotic CCl4- and TAA-LSECs (fold-change>1.5 and p-vale<0.05)compared with their respective healthy-LSECs.

2021-09-24 | GSE164878 | GEO

E-GEOD-38941

Project description:Liver Regeneration Gene Signature in Hepatitis B virus (HBV)-Associated Acute Liver Failure Identified by Gene Expression Profiling

2025-01-24 | E-GEOD-38941 | ExpressionAtlas

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data