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E-MTAB-2973

ABSTRACT: Transcription profiling by array of whole blood from 7 healthy controls and 7 multiple sclerosis (MS) patients who improved their fatigue status after a program of physical exercise

DISEASE(S): Multiple Sclerosis,Normal

PROVIDER: E-MTAB-2973 | ExpressionAtlas | 2014-11-21

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-MTAB-2973-analysis-methods.tsv	Tabular
	E-MTAB-2973-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-2973-configuration.xml	Xml
	E-MTAB-2973-configuration.xml.beforeQC	Xml
	E-MTAB-2973-percentile-ranks.tsv	Tabular

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Physical activity diminish fatigue and systemic interferon response in multiple sclerosis

Project description:Objective: To evaluate gene expression profiles in multiple sclerosis (MS) patients who improved their fatigue status after a program of physical exercise and to compare them with healthy controls (HC). Methods: A prospective longitudinal study was conducted. Gene expression in whole blood was profiled at baseline in 7 healthy controls and also in 7 fatigued-MS patients. Patients underwent a physical exercise program for 6 months, and their fatigue status and gene expression profiles were again analyzed at the end of this program. Results: MS patients showed a significant activation of genes participating in the systemic interferon response in comparison with healthy controls. Fatigue improved at the end of the physical activity program, and, in parallel, systemic activation of interferon related genes disappeared. Conclusions: Fatigue improvement following an exercise program is associated to down modulation of interferon activity at the systemic level in MS patients. Our results provide a biological basis for the observed benefit of physical exercise in MS.

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