Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-5708

ABSTRACT: RNA-Seq of pancreatic islets from beta cell-specific Pax6 knockout mice

PROVIDER: E-MTAB-5708 | ExpressionAtlas | 2019-05-14

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-5708-analysis-methods.tsv	Tabular
	E-MTAB-5708-analytics.tsv	Tabular
	E-MTAB-5708-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-5708-configuration.xml	Xml
	E-MTAB-5708-g2_g1-mvaPlot.png	Other

Items per page:

1 - 5 of 21

Similar Datasets

E-MTAB-9213

Project description:RNA-Seq of pancreatic islets from whole body knockout of lncRNA Pax6os1 mice

2021-03-22 | E-MTAB-9213 | ExpressionAtlas

E-GEOD-21860

Project description:RNA-seq of pancreatic islets from pregnant mice

2019-05-14 | E-GEOD-21860 | ExpressionAtlas

RNA-Seq of pancreatic islets from beta cell-specific Pax6 knockout mice

Project description:RNA-Seq of pancreatic islets from beta cell-specific Pax6 knockout mice

| PRJEB20579 | ENA

E-MTAB-2791

Project description:Transcription profiling by high throughput sequencing of pancreatic islets from LKB1 and AMPK knockout mice

2019-05-14 | E-MTAB-2791 | ExpressionAtlas

E-MEXP-1729

Project description:Transcription profiling by array of pancreatic islets from pancreas-specific Hnf4alpha knockout, heterozygous Hnf1alpha, and double mutant mice

2014-07-08 | E-MEXP-1729 | ExpressionAtlas

E-GEOD-73131

Project description:Transcription profiling by array of pancreatic islets from Sgpp2 knockout mice after high fat diet

2016-11-10 | E-GEOD-73131 | ExpressionAtlas

Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy

Project description:Loss of pancreatic beta cells is the central feature of all forms of diabetes. Current therapies fail to halt the declined beta cell mass. Thus, strategies to preserve beta cells are imperatively needed. In this study, we identified paired box 6 (PAX6) as a critical regulator of beta cell survival. Under diabetic conditions, the human beta cell line EndoC-bH1, db/db mouse and human islets displayed dampened insulin and incretin signalings and reduced beta cell survival, which were alleviated by PAX6 overexpression. Adeno-associated virus (AAV)-mediated PAX6 overexpression in beta cells of streptozotocin-induced diabetic mice and db/db mice led to a sustained maintenance of glucose homeostasis. AAV-PAX6 transduction in human islets reduced islet graft loss and improved glycemic control after transplantation into immunodeficient diabetic mice. Our study highlights a previously unappreciated role for PAX6 in beta cell survival and raises the possibility that ex vivo PAX6 gene transfer into islets prior to transplantation might enhance islet graft function and transplantation outcome.

2023-10-13 | GSE242338 | GEO

E-MTAB-5901

Project description:RNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice

2020-01-28 | E-MTAB-5901 | ExpressionAtlas

E-GEOD-22125

Project description:Transcription profiling by array of pancreatic islets from pregnant mice

2014-08-01 | E-GEOD-22125 | ExpressionAtlas

E-MTAB-1404

Project description:Transcription profiling by array of mouse pancreatic islets from mice with pancreatic conditional Ring1b homozygous knock-out vs littermate controls

2015-10-23 | E-MTAB-1404 | ExpressionAtlas

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data