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E-MTAB-8240

ABSTRACT: Transcriptomic (RNA-seq) analysis of wild-type and Nolz1-/- (Zfp503) mutant striatal tissue reveals altered expression of several genes involved in striatal projection neuron specification.

PROVIDER: E-MTAB-8240 | ExpressionAtlas | 2019-09-09

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-8240-analysis-methods.tsv	Tabular
	E-MTAB-8240-analytics.tsv	Tabular
	E-MTAB-8240-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-8240-configuration.xml	Xml
	E-MTAB-8240-g2_g1-mvaPlot.png	Other

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Transcriptomic (RNA-seq) analysis of wild-type and Nolz1-/- (Zfp503) mutant striatal tissue reveals altered expression of several genes involved in striatal projection neuron specification.

Project description:Transcriptomic (RNA-seq) analysis of wild-type and Nolz1-/- (Zfp503) mutant striatal tissue reveals altered expression of several genes involved in striatal projection neuron specification.

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Transcriptomic (RNA-seq) analysis of wild-type and Nolz1-/- (Zfp503) mutant striatal tissue reveals altered expression of several genes involved in striatal projection neuron specification.

Project description:Midbrain dopaminergic (DA) axons make long longitudinal projections towards target areas in the forebrain, including the striatum. After demonstrating a striatal specific requirement of transcriptional regulator Nolz1 (Zfp503) in regulating DA axon guidance and innervation, we performed RNA-seq analysis on both wild-type and Nolz1-/- mutant striatal tissue. The gene expression analysis revealed a requirement of Nolz1 in regulating striatal projection neuron specification. The RNA-seq results reveal several secreted factors that underlie the observed guidance defects and resulted in the identification of proteins that can restore DA axonal outgrowth.

2020-05-12 | E-MTAB-8240 | biostudies-arrayexpress

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