Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcriptomic (RNA-seq) analysis of wild-type and Nolz1-/- (Zfp503) mutant striatal tissue reveals altered expression of several genes involved in striatal projection neuron specification.


ABSTRACT: Midbrain dopaminergic (DA) axons make long longitudinal projections towards target areas in the forebrain, including the striatum. After demonstrating a striatal specific requirement of transcriptional regulator Nolz1 (Zfp503) in regulating DA axon guidance and innervation, we performed RNA-seq analysis on both wild-type and Nolz1-/- mutant striatal tissue. The gene expression analysis revealed a requirement of Nolz1 in regulating striatal projection neuron specification. The RNA-seq results reveal several secreted factors that underlie the observed guidance defects and resulted in the identification of proteins that can restore DA axonal outgrowth.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Lia Panman 

PROVIDER: E-MTAB-8240 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2014-03-03 | E-GEOD-55096 | biostudies-arrayexpress
2020-04-13 | GSE125290 | GEO
2010-09-21 | E-GEOD-24233 | biostudies-arrayexpress
2010-09-21 | GSE24233 | GEO
2016-03-31 | GSE77274 | GEO
2010-05-27 | E-GEOD-20547 | biostudies-arrayexpress
2022-11-02 | GSE185476 | GEO
2010-05-01 | GSE20547 | GEO
2022-12-14 | PXD034053 | Pride
2021-07-27 | GSE180913 | GEO