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E-MTAB-9148

ABSTRACT: Transcriptomic analysis of the distal colon of wild type C57BL/6N mice and mice harboring a mutation (S839I) in Gucy2c

PROVIDER: E-MTAB-9148 | ExpressionAtlas | 2021-03-22

REPOSITORIES: ExpressionAtlas

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Transcriptomic analysis of the distal colon of wild type C57BL/6N mice and mice harboring a mutation (S839I) in Gucy2c

Project description:Transcriptomic analysis of the distal colon of wild type C57BL/6N mice and mice harboring a mutation (S839I) in Gucy2c

| PRJEB38627 | ENA

Transcriptomic analysis of the distal colon of wild type C57BL/6N mice and mice harboring a mutation (S839I) in Gucy2c

Project description:A novel mouse harbouring a mutation in receptor guanylyl cyclase C (Gucy2c) that is equivalent to that seen in patients with Familial GUCY2C syndrome was established. Since patients are susceptible to colitis-like disease and IBD, RNAseq was performed on the distal colon in these mice to identify global transcriptome changes that arise as a consequence of this mutation Gucy2c.

2021-09-13 | E-MTAB-9148 | biostudies-arrayexpress

E-MTAB-7315

Project description:RNA-seq analysis of colonic intestinal epithelial cells (IECs) isolated from naive wild-type C57BL/6 mice, DSS-treated wild-type C57BL/6 mice, Il10-/- C57BL/6 mice and Il10-/- C57BL/6 mice with IEC-specific Rabgef1 deletion

2019-01-16 | E-MTAB-7315 | ExpressionAtlas

E-MTAB-7859

Project description:RNAseq of enterocytes of the jejunum and Ileum from transgene C57BL/6 mice harboring a CKIgut knock-out

2019-09-09 | E-MTAB-7859 | ExpressionAtlas

E-GEOD-83550

Project description:Ribo-zero RNAseq mouse distal colon DSS Colitis model of genetically engineered mice

2019-04-05 | E-GEOD-83550 | ExpressionAtlas

E-GEOD-59672

Project description:Expression data from DOX(doxorubicin) -treated wild type or CHIP knockout C57BL/6J mice at day 5

2015-07-29 | E-GEOD-59672 | ExpressionAtlas

E-MTAB-6547

Project description:RNAseq analysis of colon and ileum tissue from naive wild type, MR1-/- and IL-17A-/- mice

2018-06-04 | E-MTAB-6547 | ExpressionAtlas

E-MTAB-7398

Project description:RNA-seq from cortex and hippocampus of mice harboring heterozygous and homozygous deletion of Kctd13, as well as wild-type controls.

2023-06-15 | E-MTAB-7398 | ExpressionAtlas

E-MTAB-7221

Project description:Global transcriptomic profiles of blood monocytes from Hmox1 homozygous knockout mice compared to wild type controls following Mtb infection

2020-01-28 | E-MTAB-7221 | ExpressionAtlas

The gut microbiota affects the mucus barrier

Project description:Two C57BL/6 mice colonies maintained in two rooms in the same specific pathogen free (SPF) facility were found to have different gut microbiota and a mucus phenotype specific for each colony. The thickness and growth of the colon mucus was similar in the two colonies, but one colony had mucus not penetrable to bacteria or bacterial-sized beads, similar to what occurs in free-living wild mice. On the other hand, the other colony had an inner mucus layer that was penetrable to bacteria and beads. These different properties of the mucus in the two rooms were dependent on the microbiota, as the phenotypes were transmissible by transfer of ceacal microbiota to germ-free mice. Mice with an impenetrable mucus layer had increased amounts of Erysipelotrichi, while mice with a penetrable mucus layer had higher levels of Proteobacteria and TM7 bacteria in the distal colon mucus. Thus bacteria affect mucus barrier properties in ways that can have implications for health and disease.

2015-02-09 | PXD001479 | Pride

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