Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-PROT-24

ABSTRACT: Pharmacoproteomic characterisation of human colon and rectal cancer

PROVIDER: E-PROT-24 | ExpressionAtlas | 2021-05-25

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-PROT-24-analysis-methods.tsv	Tabular
	E-PROT-24-configuration.xml	Xml
	E-PROT-24-factors.xml	Xml
	E-PROT-24.condensed-sdrf.tsv	Tabular
	E-PROT-24.idf.txt	Idf

Items per page:

1 - 5 of 12

Similar Datasets

E-PROT-23

Project description:Proteomics characterization of human colon and rectal cancer

2024-02-23 | E-PROT-23 | ExpressionAtlas

Targeting β-catenin overcomes resistance to MEK inhibitor in PIK3CA mutant colon cancer

Project description:Mitogen-activated protein kinases (MEK 1/2) are central components of the RAS signaling pathway and attractive targets for cancer therapy. However, PIK3CA mutation, which commonly co-occurs with KRAS mutation, offered resistance to MEK inhibitor through activation of PI3K-AKT signaling. We identified a gene that cooperates with MEK inhibitors to forcefully treat PIK3CA mutant colon cancer cells. -catenin, a key molecule of the WNT pathway, emerged as a candidate by protein/Ab Chip array. MEK inhibitor treatment led to a decrease in -catenin in PIK3CA wild-type colon cancer cells but not in PIK3CA mutant colon cancer cells. Tumor regression was promoted by a combination of MEK inhibitor and NVP-TNS656, which targets the WNT pathway. Furthermore, combined inhibition of MEK and -catenin by NVP-TNS656 promoted tumor regression in colon cancer patient-derived xenograft (PDX) models expressing mutant PIK3CA. Taken together, we propose that inhibition of the WNT pathway, particularly -catenin, may bypass resistance to MEK inhibitor in human PIK3CA mutant colon cancer. Additionally, -catenin is a potential PD marker of MEK inhibitor resistance.

2015-08-13 | GSE71981 | GEO

Targeting β-catenin overcomes resistance to MEK inhibitor in PIK3CA mutant colon cancer

2015-08-13 | E-GEOD-71981 | biostudies-arrayexpress

Human MSI colon cancer

Project description:Human MSI colon cancer

| PRJNA666078 | ENA

Mass spectrometry data of colon cancer cell SW480 treated with Caffeic acid phenyl ethyl

Project description:Caffeic acid acetophenate exhibits anti-tumor activity. We employed proteomics to investigate the targets of caffeic acid acetophenate in human colon cancer cells. The experimental group consisted of SW480 human colon cancer cells treated with 10μM caffeic acid phenethyl for 24 hours, while the control group was treated with an equivalent volume of DMSO. Non-standard quantitative mass spectrometry was utilized to analyze differentially expressed proteins between the two groups and identify the specific target of caffeic acid acetophenate on colon cancer cells.

2023-11-01 | PXD046600 |

Human MSI colon cancer study

Project description:Human MSI colon cancer study

| PRJNA700433 | ENA

The UniProtKB/Swiss-Prot Tox-Prot program: A central hub of integrated venom protein data.

Project description:Animal toxins are of interest to a wide range of scientists, due to their numerous applications in pharmacology, neurology, hematology, medicine, and drug research. This, and to a lesser extent the development of new performing tools in transcriptomics and proteomics, has led to an increase in toxin discovery. In this context, providing publicly available data on animal toxins has become essential. The UniProtKB/Swiss-Prot Tox-Prot program (http://www.uniprot.org/program/Toxins) plays a crucial role by providing such an access to venom protein sequences and functions from all venomous species. This program has up to now curated more than 5000 venom proteins to the high-quality standards of UniProtKB/Swiss-Prot (release 2012_02). Proteins targeted by these toxins are also available in the knowledgebase. This paper describes in details the type of information provided by UniProtKB/Swiss-Prot for toxins, as well as the structured format of the knowledgebase.

| S-EPMC3393831 | biostudies-literature

Homo sapiens

Project description:SMC1A targeting in human colon cancer

| PRJNA1016101 | ENA

Temposeq of human colon cancer tissue

Project description:Temposeq of human colon cancer tissue

| PRJEB63261 | ENA

E-PROT-40

Project description:Human colon biopsies (healthy and Ulcerative Colitis) LC-MS/MS

2022-01-07 | E-PROT-40 | ExpressionAtlas