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E-TABM-725

ABSTRACT: Transcription profiling of rat heart from Lewis strain immunized with a peptide of human alpha1A-adrenergic receptor

PROVIDER: E-TABM-725 | ExpressionAtlas | 2015-11-02

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-TABM-725-analysis-methods.tsv	Tabular
	E-TABM-725-atlasExperimentSummary.Rdata	Rdata
	E-TABM-725-configuration.xml	Xml
	E-TABM-725-percentile-ranks.tsv	Tabular
	E-TABM-725.condensed-sdrf.tsv	Tabular

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Transcription profiling of rat heart from Lewis strain immunized with a peptide of human alpha1A-adrenergic receptor

Project description:Gene expression profiles in hearts of Lewis rats immunized with a peptide of human alpha1A-adrenergic receptor. The pathophysiological relevance of chronic autoantibodies against alpha-1A-adrenergic receptor stimulation in rats was investigated. Lewis rats were immunized using synthesized peptides of second extracellular loop of the human alpha-1A-adrenergic receptor and raised for one year. The gene expression in hearts of three immunized and three control rats were analyzed using Affymetrix Rat Genome 230 2.0 Arrays.

2010-06-15 | E-TABM-725 | biostudies-arrayexpress

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Transcriptomic response in the heart and kidney to different types of antihypertensive drug administration

Project description:To unravel antihypertensive drug-induced gene expression changes that are potentially related to the amelioration of end-organ damages, we performed in vivo phenotypic evaluation and transcriptomic analysis on the heart and the kidney, with administration of antihypertensive drugs to two inbred strains of (i.e., hypertensive and normotensive) rats. We chose to use six antihypertensive classes: enalapril (angiotensin converting enzyme inhibitor), candesartan (angiotensin receptor blocker), hydrochlorothiazide (diuretics), amlodipine (calcium-channel blocker), carvedilol (vasodilating beta-blocker) and hydralazine. In the tested rat strains, four of six drugs, including two renin-angiotensin system (RAS) inhibitors, were effective for BP lowering, whereas the remaining two drugs were not. Besides BP lowering, there appeared to be some inter-drug heterogeneity in phenotypic changes, such as suppressed body weight (Bw) gain and Bw-adjusted heart weight reduction. For the transcriptomic response, a considerable number of genes showed prominent mRNA expression changes either in a BP-dependent or BP-independent manner with substantial diversity between the target organs. Noticeable changes of mRNA expression were induced particularly by RAS blockade, e.g., for genes in the natriuretic peptide system (Nppb and Corin) in the heart and for those in the RAS/ kallikrein-kinin system (Ren and rat Klk1 paralogs) and those related to calcium ion binding (Calb1 and Slc8a1) in the kidney. This submission includes the kidney data.

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