Dataset Information

Goldbeter1990_CalciumSpike_CICR

ABSTRACT: The model reproduces the time profile of cytosolic and intracellular calcium as depicted in the upper panel of Fig 2 in the paper. The model was successfully tested on MathSBML and Jarnac. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.For more information see the terms of use.To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

SUBMITTER: Harish Dharuri

PROVIDER: BIOMD0000000098 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

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			Action	DRS
	BIOMD0000000098?filename=BIOMD0000000098-biopax2.owl	Owl
	BIOMD0000000098?filename=BIOMD0000000098-biopax3.owl	Owl
	BIOMD0000000098?filename=BIOMD0000000098-matlab.m	Other
	BIOMD0000000098?filename=BIOMD0000000098-octave.m	Other
	BIOMD0000000098?filename=BIOMD0000000098.m	Other

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Publications

Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation.

Goldbeter A A Dupont G G Berridge M J MJ

Proceedings of the National Academy of Sciences of the United States of America 19900201 4

In a variety of cells, hormonal or neurotransmitter signals elicit a train of intracellular Ca2+ spikes. The analysis of a minimal model based on Ca2(+)-induced Ca2+ release from intracellular stores shows how sustained oscillations of cytosolic Ca2+ may develop as a result of a rise in inositol 1,4,5-trisphosphate (InsP3) triggered by external stimulation. This rise elicits the release of a certain amount of Ca2+ from an InsP3-sensitive intracellular store. The subsequent rise in cytosolic Ca2+ ...[more]

PMID: 2304911

Publication: 1/2

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